- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
The role of bone marrow aspirate and bone marrow biopsy in the diagnosis of multiple myeloma | ||
| The Medical Journal of Basrah University | ||
| Article 11, Volume 42, Issue 1, June 2024, Pages 82-91 PDF (411.89 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2024.147219.1201 | ||
| Author | ||
| Noor Nayef Assi* | ||
| Basrah health department | ||
| Abstract | ||
| Background: Multiple myeloma (MM) is a malignancy of terminally differentiated clonal plasma cells. Expansion of the malignant plasma cells throughout the bone marrow (BM) leads to cytopenias, bone resorption and production of monoclonal immunoglobulins known as M components or paraproteins. BM analysis is an important element in establishing the diagnosis of MM. The study aims to evaluate the diagnostic yield of bone marrow aspirate and bone marrow biopsy in patients with MM. and to Compare the newly diagnosed and follow-up cases (regarding the bone marrow examination, hematological and biochemical parameters). Methods: This is a cross-sectional study conducted from the first of August 2022 to the first of August 2023, and included 32 patients with MM. The patients were diagnosed at the Basrah Oncology and hematology center. The laboratory parameters and BM examination were analyzed and correlated. Immunohistochemical staining with CD138 was done for selected cases. Results: Anemia (Hemoglobin (Hb) < 10 g/dL) was seen in 59.4% of total cases. Hypercalcemia was found in 9.4% of total cases. Serum creatinine of more than 2 mg/dL was found in 25% of total cases. Monoclonal (M) protein was positive in 84.4% of total cases. There is a significant difference between the positive results of BMA and BMB. Conclusions: BMA and BMB complement each other for BM evaluation. The combined use of BMA smears, HE stained BMB sections and CD138 IHC is beneficial in obtaining the most clinically relevant BM plasma cell percentage. | ||
| Keywords | ||
| Keywords: multiple myeloma (MM); BMA; BMB | ||
|
Statistics Article View: 3,032 PDF Download: 231 |
||