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Insulin Resistance and ß-cell Function in Patients with Non-alcoholic Fatty Liver Disease | ||
| The Medical Journal of Basrah University | ||
| Article 9, Volume 42, Issue 1, June 2024, Pages 69-82 PDF (405.1 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2024.147228.1199 | ||
| Authors | ||
| ahlam kadhim alshadood* 1; Salman Kadhim Ajlan2 | ||
| 1College of Medicine, University of Basrah | ||
| 2Department of Biochemistry, College of Medicine, Basrah University , Basrah ,IRAQ | ||
| Abstract | ||
| Background: Nonalcoholic fatty liver disease is a common hepatic disorder marked by the accumulation of lipids in the liver, frequently accompanied by metabolic disturbances, including insulin resistance (IR), a condition where cells become less responsive to insulin's glucose-lowering effects, important in the evolution and progression of NAFLD. Objective: To evaluate the degree of IR and β-cell function among patients with NAFLD. Methods: A case-control study was conducted on 75 patients diagnosed with NAFLD and 81 control subjects. Fasting blood glucose, glycated haemoglobin and insulin were determined in all participants. In addition, insulin resistance and pancreatic ß- cell function were estimated by HOMA-IR and HOMA-B equations respectively. Results: HOMA-IR and HOMA-B were significantly higher among patients with NAFLD (3.59 ± 3.52, 277.57 ± 169.89) than controls (2.56±1.39, 153.46±106.17) respectively, with the comparative P < 0.05 and P < 0.001. In addition, FBG, HbA1c and insulin were significantly higher among patients with NAFLD than control subjects, P < 0.01. Conclusion: The strong association between HOMA-IR and NAFLD imply the role of IR in the pathogenesis of NAFLD. The significant elevation of HOMA-B among patients with NAFLD reflects the degree of hyperinsulinaemia secondary to IR. | ||
| Keywords | ||
| Keywords; NAFLD, insulin resistance, β-cell function | ||
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