Hussein, B., Mahdi, Q. (2024). The Role of Thyroglobulin as Predictive Biomarker for Diagnosis of Differentiated Thyroid Cancer in Al- Imammein Al- Kadhumain Medical City. , 23(2), 183-190. doi: 10.52573/ipmj.2024.183818
Bashar Khalid Hussein; Qahtan Adnan Mahdi. "The Role of Thyroglobulin as Predictive Biomarker for Diagnosis of Differentiated Thyroid Cancer in Al- Imammein Al- Kadhumain Medical City". , 23, 2, 2024, 183-190. doi: 10.52573/ipmj.2024.183818
Hussein, B., Mahdi, Q. (2024). 'The Role of Thyroglobulin as Predictive Biomarker for Diagnosis of Differentiated Thyroid Cancer in Al- Imammein Al- Kadhumain Medical City', , 23(2), pp. 183-190. doi: 10.52573/ipmj.2024.183818
Hussein, B., Mahdi, Q. The Role of Thyroglobulin as Predictive Biomarker for Diagnosis of Differentiated Thyroid Cancer in Al- Imammein Al- Kadhumain Medical City. , 2024; 23(2): 183-190. doi: 10.52573/ipmj.2024.183818

The Role of Thyroglobulin as Predictive Biomarker for Diagnosis of Differentiated Thyroid Cancer in Al- Imammein Al- Kadhumain Medical City

Iraqi Postgraduate Medical Journal
Article 10, Volume 23, Issue 2, April 2024, Pages 183-190    PDF (241.08 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2024.183818
Authors
Bashar Khalid Hussein* 1; Qahtan Adnan Mahdi2
1Al-Rusafa Health Directorate/Al-Fahama PHC, Baghdad, Iraq
2College of Medicine/ Al-Nahrain University, Baghdad, Iraq
Abstract
BACKGROUND:
Several line of evidence have indicated the role serum thyroglobulin (Tg) concentrations in differentiating malignant from benign thyroid cancer. However, such a role in differentiating follicular from papillary thyroid carcinoma still needs more studies.
OBJECTIVE:
To evaluate the prognostic value of preoperative serum Tg level in differentiation between follicular and papillary thyroid cancer in patients undergoing thyroidectomy.
PATIENTS AND METHODS:
This is a retrospective single center study including 50 patients diagnosed with thyroid carcinoma and scheduled to have total thyroidectomy.  Patients‟ demographic and final histopathology reports were obtained. Serum Tg was measure preoperative.
RESULTS:
Papillary thyroid carcinoma (PTC) was reported in 38 patients (76%), while the other 12 patients (24%) were found to have follicular thyroid carcinoma (FTC). The sensitivity and specificity of Tg in detection of PTC was 60.53% and 33.33%. While the sensitivity and specificity of Tg was 33.33% and 60.52% in predicating FTC. Hypocalcemia was the most common complication, up to 10%. There was no significant relationship between any of the included demographic or clinical factors and the type of cancer or the development of complications.
CONCLUSION:
Thyroglobulin has a moderate sensitivity for detection PTC (60.53%), while it has poor sensitivity for detection FTC (33.33%).
 
 
Keywords
Follicular and papillary thyroid carcinoma; thyroglobulin; sensitivity and specificity
Supplementary Files
References
  1. Younis E. Oncogenesis of Thyroid Cancer. Asian Pac J Cancer Prev. 2017; 18:1191-99.
  2. Furukawa K, Preston D, Funamoto S, et al. Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure. Int J Cancer. 2013;132:1222–26.
  3. Nikiforov YE. Radiation-induced thyroid cancer: what we have learned from chernobyl. Endocr Pathol. 2006;17:307–17.
  4. Hughes DT, Haymart MR, Miller BS, Gauger PG, Doherty GM. The most commonly occurring papillary thyroid cancer in the United States is now a micro-carcinoma in a patient older than 45 years. Thyroid. 2011; 21:231– 36.
  5. Shah JP. Thyroid carcinoma: epidemiology, histology, and diagnosis. Clin Adv Hematol Oncol. 2015;13:3-6.
  6. Nishiyama RH, Ludwig GK, Thompson NW. The prevalence of small papillary thyroid carcinomas in 100 consecutive necropsies in an American population. In: DeGroot LJ, editor. Radiation-Associated Thyroid Carcinoma. New York: Grune &
  7. Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. The Lancet.:2016;388:2783-95.
  8. Howlader N NA, Krapcho M, Miller D, et al. editors. SEER Cancer Statistics Review, 1975-2013. Bethesda, MD: National Cancer Institute; April 2016. http://seer.cancer.gov/csr/1975_2013/, based on November 2015 SEER data submission, posted to the SEER website
  9. Dralle, Henning et al. “Follicular cell-derived thyroid cancer.” Nature reviews. Disease primers 1 15077. 10 Dec. 2015, doi:10.1038/nrdp.2015.77.
  10. LiVolsi, Virginia A. “Papillary thyroid carcinoma: an update.” Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 24 Suppl 2 (2011): S1-9. doi:10.1038/modpathol.2010.129
  11. Lee CC  AM,  Junit  SM,  Ng  KL,  Wong  SY,  Ramli  NSF,  Hashim    Malignant transformation of benign thyroid nodule is caused by prolonged H2O2 insult that interfered with the STAT3 pathway?. Int J Clin Exp Med. 2016;9:18601-17.
  12. McHenry CR, Phitayakorn R. Follicular adenoma and carcinoma of the thyroid gland. Oncologist. 2011;16:585-93.
  13. Ahmadi S, Stang M. Hürthle cell carcinoma: Current OncoTargets and Therapy. 2016;9:6873 .
  14. Montone KT, Baloch ZW, LiVolsi VA. The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: A surgical pathology and cytopathology review. Archives of Pathology & Laboratory Medicine. 2008;132:1241-50.
  15. Goffredo P, Roman SA, Sosa JA. Hurthle cell carcinoma. 2013;119:504-11.
  16. Feldkamp J, Führer D, Luster M, et al. Fine Needle Aspiration in the Investigation of Thyroid Nodules. Dtsch. Arztebl. Int. 2016; 113: 353–59.
  17. Schmidbauer B, Menhart K, Hellwig D, Grosse J. Differentiated Thyroid Cancer-Treatment: State of the Art. Int J Mol Sci. 2017;18:1292.
  18. Dralle H, Musholt TJ, Schabram J, et al. et al. German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors. Langenbecks Arch. Surg. 2013;398: 347–75.
  19. Washington D.C.: American Association for Clinical Chemistry; c2001– 2018. Thyroglobulin; [updated 2017 Nov 9; cited 2018 Aug 8].
  20. Asari R, Koperek O, Scheuba C, et al. Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. Annals of Surgery. 2009;249:1023–31.
  21. Lang BH-H, Lo C-Y, Chan W-F, Lam K-Y, Wan K-Y. Prognostic factors in papillary and follicular thyroid carcinoma: their implications for cancer staging. Annals of Surgical Oncol 2007;14:730–38.
  22. D‟Avanzo A, Treseler P, Ituarte PHG, et Follicular thyroid carcinoma: histology and prognosis. Cancer. 2004;100:1123–29.
  23. Petric R, Besic H, Besic N. Preoperative serum thyroglobulin concentration as a predictive factor of malignancy in small follicular and Hurthle cell neoplasms of the thyroid gland. World J Surg Oncol 2014;12:282.
  24. Petric R, Perhavec A, Gazic B, et al. Preoperative serum thyroglobulin concentration is an independent predictive factor of malignancy in follicular neoplasms of the thyroid gland. J Surg Oncol 2012;105: 351–56.
  25. Suh I, Vriens MR, Guerrero MA, et al.: Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroid. Am J Surg 2010;200:41–
  26. Cooper DS, Doherty GM, Haugen BR, et al.: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2009;19: 1167–214.
  27. Rasmussen LB, Ovesen L, Bu¨low I, et al.: Relations between various measures of iodine intake and thyroid volume, thyroid. nodularity, and serum thyroglobulin. Am J Clin Nutr 2002;76: 1069–76.
  28. Ringel, M.D.; Nabhan, F. Approach to follow-up of the patient with differentiated thyroid cancer and positive anti-thyroglobulin antibodies. J. Clin. Endocrinol. Metab. 2013;98:3104–10.
  29. Girardi FM, Silva LM, Flores CD. A predictive model to distinguish malignant and benign thyroid nodules based on age, gender and ultrasonographic features. Braz J Otorhinolaryngol. 2019;85:24-31.
  30. Hulikal N, Re A, Banoth M, Chowhan AK, Yutla M, Sachan A. Can preoperative serum thyroglobulin levels predict the risk of malignancy? Results from prospective analysis of biochemical predictors of malignancy in thyroid nodules. Acta Otorhinolaryngol Ital. 2020;40:33-37.
  31. Park VY, Kim EK, Kwak JY, Yoon JH, Moon HJ Malignancy risk and characteristics of thyroid nodules with two consecutive results of atypia of undetermined significance or follicular lesion of undetermined significance on cytology. Eur Radiol 2015; 25: 2601-7.
  32. Teixeira GV, Chikota H, Teixeira T, Manfro G, Pai SI, Tufano RP Incidence of malignancy in thyroid nodules determined to be follicular lesions of undetermined significance on fine-needle aspiration. World J Surg 2012;36:69-74.
  33. Strazisar B, Petric R, Sesek M, Zgajnar J, Hocevar M, et al. Predictive factors of carcinoma in 279 patients with Hürthle cell neoplasm of the thyroid gland. J Surg Oncol 2010;101:582-86.
  34. Liu J, Sun W, Dong W, et al. Risk factors for post-thyroidectomy haemorrhage: a meta-analysis. Eur J Endocrinol. 2017;176:591–602.
  35. Edafe O, Antakia R, Laskar N, Uttley L, Balasubramanian SP. Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia. Br J Surg. 2014;101:307–20.
  36. Daher R, Lifante JC, Voirin N. et al; CATHY Study Group. Is it possible to limit the risks of thyroid surgery? Ann Endocrinol (Paris). 2015;76:1S16–26.
  37. Chiang FY, Wang LF, Huang YF, et al. Recurrent laryngeal nerve palsy after thyroidectomy with routine ident.
 

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