In-Vitro Quality Assessment of Selected Marketed Cetirizine Tablets Products in Iraq

Mohamed, Asmaa Abdelaziz

	In-Vitro Quality Assessment of Selected Marketed Cetirizine Tablets Products in Iraq
Al-Zahraa Journal for Health and Medical Sciences
Volume 2, Issue 2, June 2024, Pages 52-61 PDF (583.31 K)
Document Type: Research Article
Author
Asmaa Abdelaziz Mohamed^*
College of Pharmacy, Al-Zahraa University for women, Karbala, Iraq
Abstract
This investigation aimed to evaluate the quality of specific cetirizine HCL products available in pharmacies in Iraq. Various measures can ensure their quality and efficacy, such as utilizing quality control metrics, specifically the variability of weight, friability, content, disintegration time, and release. Allercet, Allereset, Ceritec, and Cetirizine-Ozon were categorized according to their weight range. Depending on the formulation, the disintegration time for Allercet, Allereset, Ceritec, and Cetrizine-Ozon was 4.5, 5.5, 6, and 12 minutes, respectively. All products had released more than 80% of their content after 30 minutes, and the content homogeneity was within the limit. The disintegration rate of Allercet was the quickest, whereas that of Cetrizine-Ozon was the slowest. Moreover, Allercet tablets revealed the quickest disintegration and release 81% after 10 min and may exhibit the quickest response after administration. The results indicated that all products met the specified requirements of the United States and British Pharmacopeia. However the best brand was Allercet which had the fastest release (81% after 10 minutes) and the least disintegration time.
Keywords
Cetrizine; assessment; hardness; dissolution; disintegration
Supplementary Files Volume 2, Issue 2, September 2024 (6) (2)_split.pdf ZJHMS_Volume 2_Issue 2_split (4).pdf
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