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The Potential Role of Interferon-Alpha in Severity of Coronavirus Disease 2019 | ||
| Al-Zahraa Journal for Health and Medical Sciences | ||
| Volume 2, Issue 2, June 2024, Pages 95-102 PDF (374.06 K) | ||
| Document Type: Research Article | ||
| Authors | ||
| Batool Hassan Al-Ghurabi* 1; Haifa Hmood Kareem2 | ||
| 1College of Dentistry\\\\University of Baghdad | ||
| 2Department of Basic Science, College of Dentistry, University of Baghdad. | ||
| Abstract | ||
| The main point in COV-2 infection could be depletion of natural antiviral defenses, as well as the elevated cytokines secretion. IFN disruption is a crucial factor in COVID-19 pathology, according to recent research. The goal of this research was to elucidate interferon-alpha concentration, as well as to examine its association with COVID-19 severity. This case-control research included eighty-five subjects (fifty patients with SARS-CoV-2 and thirty-five controls) with age range (18-77) years old. The oral hygiene index was used to determine oral health. The levels of IFN- were measured in serum using an ELISA. This study showed decrease (P˂0.03) in IFN-alpha among patients compared to controls. Also, a highly considerable difference (p˂0.001) in IFN-alpha concentration among patients’ groupings, with no significant difference between the moderate and mild groups. Furthermore, there was no significant variation in interferon-alpha levels between good oral hygiene and those with poor oral hygiene (p=0.35). A Significant decrease in interferon-alpha among patients provides evidence of inappropriate immune response in patients, and the association of low interferon-alpha with the severity of disease indicated that this cytokine can be utilized as biomarkers of disease activity. | ||
| Keywords | ||
| corona virus; innate immune response; cytokines; oral health; viral infection | ||
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