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Efficacy of Novel Antimicrobial Therapies for Treating Staphylococcus Infections in Wistar Rats | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Volume 17, Issue 1, August 2024, Pages 35-41 PDF (720.39 K) | ||
| Author | ||
| Noman D. Salih | ||
| Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management & Science University, Selangor, Malaysia. | ||
| Abstract | ||
| The novel semisynthetic lipoglycopeptide dalbavancin has enhanced antibacterial action against a wide range of gram-positive bacteria. This current study was conducted to evaluate the efficacy of dalbavancin in treating pathogenic Staphylococcus infections in Wistar rats. The experiment included 20 animals, divided into 2 groups, a control group and an experimental group. All rats were anaesthetized and had a Kirschner wire plus clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate placed into their proximal tibia. The experimental group (10 rats) were treated with a loading dosage of dalbavancin (20 mg/kg) administered throughout 4 weeks following the induction, while the control group (10 rats) were left untreated. Microbiological analysis was performed on tibial bones and Kirschner wires within 24 hours after the last dosage was given. In comparison with the control group, the dalbavancin-treated group showed improvement in quantitative bacterial cultures of osseous tissue. After four weeks of treatment with dalbavancin, there were no signs of induced glycopeptide-/lipoglycopeptide-resistant strains. In conclusion, this study confirmed that treatment with dalbavancin was effective in the treatment of experimental implant-related MRSA osteomyelitis. However, the therapeutic effectiveness of dalbavancin in treating S. aureus infections still needs further investigation; ideally, it should be studied in conjunction with biofilm-active medicines. | ||
| Keywords | ||
| Dalbavancin; Osteomyelitis; Methicillin-Resistant Staphylococcus aureus (MRSA); Wistar Rats | ||
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