Circadian Rhythms of Oxidant-Antioxidant Agents, HPA Axis and Protein Carbonyl Content in Serum, Brain and Adrenal Gland Tissues

Khamees Abed, Sabea; Alrawi, Thabit Jassim; Al-Azawi, Tahani S.S.

doi:10.37940/AJVS.2021.14.1.4

	Circadian Rhythms of Oxidant-Antioxidant Agents, HPA Axis and Protein Carbonyl Content in Serum, Brain and Adrenal Gland Tissues
Al-Anbar Journal of Veterinary Sciences
Volume 14, Issue 1, September 2021, Pages 41-47 PDF (678.9 K)
Document Type: Research Paper
DOI: 10.37940/AJVS.2021.14.1.4
Authors
Sabea Khamees Abed^* ¹; Thabit Jassim Alrawi²; Tahani S.S. Al-Azawi³
¹Dept.of Physiology & Pharmacology/College of Veterinary Medicine/University of Fallujah, Iraq
²Dept.of Public Health/College of Veterinary Medicine/University of Fallujah, Iraq
³AL-Zahraa University for Women
Abstract
The aim of this experiment is to study the circadian rhythm of oxidant-antioxidant components in the body. A total of 20 adult male rabbits were divided into 2 groups (G1and G2)and kept in 2 different rooms. Serum was isolated after blood collection at 12 A.M or 12 P.M respectively from G1 and G2.The results reveal a significant elevation in serum GSH, MDA and SOD during night hours. The B-endorphin showed a value of 84.36±1.36 in rabbits serum during night compared with 53.23±1.12 during day hours. Serum ACTH and cortisone concentration during night hours expressed a value of 71.03±0.16 and 24.46±0.38 compared to 52.80±0.37 and 11.80±0.57 during day hours respectively. Protein carbonyl contents shows a regular variation between serum and tissues during day and night hours. It was concluded that the oxidant-antioxidant imbalance lead to such variation between day and night hours due to activities and metabolism. Extensive research is needed to minimize and overlap such stress.
Keywords
Oxidant-antioxidant; B-endorphin; Protein carbonyl contents

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