The Effect of Diabetes on the Physiological Parameters in Male Rats

Mukhlif, Ziadoon Fawzi; Rahim, Saleh M; Jamal, Mustafa Nuhad Jumaa

doi:10.37940/AJVS.2020.13.1.8

	The Effect of Diabetes on the Physiological Parameters in Male Rats
Al-Anbar Journal of Veterinary Sciences
Volume 13, Issue 1, August 2020, Pages 66-73 PDF (1.58 M)
Document Type: Research Paper
DOI: 10.37940/AJVS.2020.13.1.8
Authors
Ziadoon fawzi mukhlif¹; Saleh M Rahim^* ²; Mustafa nuhad jumaa jamal³
¹Dept. of biology, College of education for pure science, University of Anbar
²Dept. of Biology, College of Science, University of Kirkuk
³Dept. of Biology, College of Science, University of Anbar
Abstract
The aim of this study is to assess the effects of high blood glucose levels in male rats with diabetes induced by alloxan on their physiological conditions. Diabetes mellitus is a category of metabolic hyperglycemia disorders caused by insufficient body production or pancreatic action. In addition to hyperglycemia, a number of other factors are also important for pathogenesis, such as Hyperlipidemics and cortisol oxidative. Forty-five mature male rats were used in this study, these were divided into 3 groups, Control group(G1) : gavage distilled water, Group2(G2): injection intraperitoneally with Alloxan150 mg/kg bw for two weeks, and Group3(G3): injection intraperitoneally with Alloxan 150mg/kg bw for twenty-four days. Blood samples taken from all groups estimation of Peroxynitrite, GSH, CAT, and SOD concentrations%. The findings revealed a significant improvement in diabetic classes in glucose (p<0.05) and peroxynitrite relative to control (G1). Diabetic concentrations of (G2, G3) relative to the control group (G1) were substantially reduced in SOD, GSH, CAT, and diabetes-mediated (P < 0,05). In conclusion, diabetes can cause significant changes in SOD, GSH, and CAT levels in rats.
Keywords
Rats; Diabetes; Physiological parameters; SOD; GSH and CAT

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