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Study the Physiological Effects of Finasteride (Prostacare) on some Reproductive Parameters in Male Rats (Rattus- Rattus) | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Volume 13, Issue 1, August 2020, Pages 91-96 PDF (1.08 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.37940/AJVS.2020.13.1.11 | ||
| Author | ||
| Assad. H. Eisa AL-Edany | ||
| Department of public health, College of Veterinary Madicine, University of Basrah, Iraq | ||
| Abstract | ||
| This study was conducted in the veterinary medicine college in Basrah University animal house and aimed to investigate the effect of finasteride (prostacare) on male some parameters reproductive system in albino male rats (Rattua-Rattus). Thirty-six mature male rats with body weight 200-210 g and age 8 weeks were randomly divided into three groups (12 animals in each group). The first group was considered as a control group and treated orally with normal saline (0.9%N.S)during the experimental 30 days, the second group was treated with finasteride(0.016mg/kg of body weight orally during the experimental(30)days. and the third group was administrated finasteride(0.032mglkg of body weight orally during the experimental 30 days. The results showed a significant decrease in the sperm count, sperm motility, and live sperm and an increase in dead sperm percentage as well as a significant decrease in the level of reproductive hormones (testosterone, LH and FSH) in the treated group with finasteride compared with a control group, from this study, it was concluded that the finasteride has undesired physiological effects on fertility in albino male rats (Rattus-Rattus). | ||
| Keywords | ||
| Finasteride; Reproductive Parameters; Rats | ||
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