Ghanim, Z., Alkotaji, M., Qazzaz, M. (2024). Principles and New Strategies in Diabetic Foot Management. , 21(4), 171-181. doi: 10.33899/iraqij.p.2024.150018.1100
Zinah Sabah Ghanim; Myasar Alkotaji; Mohannad E. Qazzaz. "Principles and New Strategies in Diabetic Foot Management". , 21, 4, 2024, 171-181. doi: 10.33899/iraqij.p.2024.150018.1100
Ghanim, Z., Alkotaji, M., Qazzaz, M. (2024). 'Principles and New Strategies in Diabetic Foot Management', , 21(4), pp. 171-181. doi: 10.33899/iraqij.p.2024.150018.1100
Ghanim, Z., Alkotaji, M., Qazzaz, M. Principles and New Strategies in Diabetic Foot Management. , 2024; 21(4): 171-181. doi: 10.33899/iraqij.p.2024.150018.1100

Principles and New Strategies in Diabetic Foot Management

Iraqi Journal of Pharmacy
Article 5, Volume 21, Issue 4, December 2024, Pages 171-181    PDF (697.52 K)
Document Type: Review Paper
DOI: 10.33899/iraqij.p.2024.150018.1100
Authors
Zinah Sabah Ghanim1; Myasar Alkotaji2; Mohannad E. Qazzaz* 1
1Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq
2Department of Pharmaceutics, College of Pharmacy, Ninevah University, Mosul, Iraq
Abstract
Background: Diabetic foot ulcers (DFU) occur in up to 15% of all diabetic patients and are a leading cause of nontraumatic amputation worldwide. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk.The high rates of therapy failure have resulted in the development of new therapies. Aim: Highlight the current trends in DFU management that could replace or complement the classical strategy for the management of DFU, as well as selective and targeted strategies that are needed to improve the healing process. Method: The authors, with precision, conducted an exhaustive literature search by thoroughly exploring the Science Direct, Scopus, PubMed, and Web of Science databases. They specifically sought out published studies and original articles that were featured in esteemed peer-reviewed journals and reported on original research. Conclusion: These new techniques are promising but still mostly unproven. New and generally more expensive therapies should be seen as adding to traditional approaches and not a replacement for conventional approaches.

Highlights
  • Treatment of infection, revascularization, debridement still fist line treatment for diabetic foot.
  • The new therapies should be considered additive therapy and only be used in cases where wounds are not healing.
  • Nanotechnology has created novel opportunities for delivering drugs, involveing the administration of biomolecules.
  • Tissue engineering techniques for wound repair would necessitate the optimization of both biological and mechanical effectors.
Keywords
Diabetic foot; Wound dressing; Growth factor; Tissue engineering; Nanotechnology
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