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Ovarian Epithelial Cancers: A Pathological Study of 164 Cases | ||
| Al- Anbar Medical Journal | ||
| Article 13, Volume 20, Issue 2, December 2024, Pages 200-206 PDF (13.37 M) | ||
| Document Type: Original articles | ||
| DOI: 10.33091/amj.2024.150051.1732 | ||
| Authors | ||
| Intisar Salim Pity1; Ghasaq Muhanad Kareem2; Dildar Haji Musa* 3; Abdulkareem Younis Sulaiman4; Shang Mohammed Salih Amedi5; Hayam Mostafa Rasoul6; Yasmine Hussien Abdalwahab1; Dani Badal Hayder7 | ||
| 1Department of Pathology, College of Medicine, University of Duhok, Duhok, Iraq | ||
| 2Department of Basic Sciences, College of Medicine, University of Zakho, Zakho, Iraq | ||
| 3Department of Surgery, College of Medicine, University of Duhok, Duhok, Iraq | ||
| 4Department of Pathology, College of Medicine, University of Mosul, Mosul, Iraq | ||
| 5Department of Obstetrics and Gynecology, College of Medicine, University of Duhok, Duhok, Iraq | ||
| 6Department of Obstetrics and Gynecology, Obstetrics and Gynecology Teaching Hospital, Directorate of Health in Duhok, Duhok, Duhok, Iraq | ||
| 7Azadi Teaching Hospital, Directorate of Health in Duhok, Duhok, Duhok, Iraq | ||
| Abstract | ||
| Background: Foremost, the diagnosis of ovarian carcinoma is light microscopic in nature. However high-graded tumors and some equivocal cases may require contemporary tests. Objectives: To examine ovarian carcinoma types in Duhok-Iraq using morphology and available immunohistochemical panels. Materials and Methods: In this retrospective cross-sectional study, paraffin blocks of 164 ovarian carcinoma cases were retrieved from Duhok pathology centers between January 2012 and December 2022. Tumor microsections were taken from these paraffin blocks, stained with Hematoxylin and Eosin (H&E), and examined under the light microscope. After morphologic diagnosis, tumors were classified. High-grade and equivocal cases were subjected to different immunohistochemical panels depending on the light microscopical morphology and the available antibodies. The immunohistochemical technique applied was the automated immune-stainer (Dako-Denmark) on deparaffinized tumor sections using the avidin-biotin–peroxidase complex technique. Results: The study cases included 125 primary and 39 metastatic carcinomas. All women were over 20 years with a mean age of 42.8 years. Among the primary tumors, high-grade serous carcinoma (33.5%) was the commonest, followed by mucinous carcinoma (22.6%), endometrioid carcinoma (14%), clear cell carcinoma (2.4%) and transitional cell carcinoma (1.2%). The remaining primaries comprised 4 (2.4%) Malignant Mixed Mullerian tumor. The 39 metastatic carcinomas were adenocarcinomas, average age was 36.9 years. Sites of origin included: 18 colonic (including appendix), 7 gastric, 4 endometrial, 5 breast, 3 pancreatobiliary, and 2 ampullary carcinomas. Conclusion: High grade serous carcinoma topped the list of ovarian carcinoma cases (primary and metastatic). Diagnosis of most carcinoma cases was made using routine H&E light microscopic sections. Difficulties arise in high-grade and metastatic cases, particularly cases exclusive to an ovary. Metastatic cases have primarily emerged from the colon (including appendix), stomach, endometrium, pancreatobiliary, breast, and ampulla. Such cases need contemporary tests, like immunohistochemistry. | ||
| Keywords | ||
| Primary ovarian carcinoma; Epithelial ovarian cancer; Metastatic ovarian cancer; Immunohistochemistry | ||
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