Invastigate The Serum Level of Interleukin-4 In Patients with Chronic Rhinosinositis with Nasal Polyps and Healthy Individuals

Zidan, Hiba Hamed; Kamel, Rusul Hamza; Abo-tbeak, Zainab Jawad

doi:10.57238/tpb.2024.152706.1010

	Invastigate The Serum Level of Interleukin-4 In Patients with Chronic Rhinosinositis with Nasal Polyps and Healthy Individuals
Trends in Pharmaceutical Biotechnology
Volume 2, Issue 1, September 2024, Pages 17-21 PDF (2.28 M)
Document Type: Original article
DOI: 10.57238/tpb.2024.152706.1010
Authors
Hiba Hamed Zidan^* ; Rusul Hamza Kamel; Zainab Jawad Abo-tbeak
Department of Clinical Laboratory Sciences, College of Pharmacy, University of Al-Qadisiyah, Al-Qadisiyah 58002, Iraq.
Abstract
Objective: Interleukin-4 plays several biological roles, including stimulating the proliferation of activated B and T cells and differentiating B cells into plasma cells. This study aimed to determine whether the etiology of chronic rhinosinusitis with nasal polyps (CRSwNPs) is associated with serum levels of interleukin-4. Patients and Methods: a blood samples from 35 Iraqi patients—21 men and 14 women—who had nasal polyps as well as a control group of 35 healthy volunteers were collected. The serum was then separated in a plain tube, and an enzyme-linked immunosorbent assay method was used to determine the optical density of Interleukin-4 in the serum (ELISA) Results: Serum levels of interleukin-4 were significantly higher in the patient group compared to the control group (P < 0.001). There was no significant correlation between serum interleukin-4 levels and age or gender in either group. Conclusions: Individuals who have NPs had elevated degrees of IL-4.
Keywords
Serum; ELISA; Interleukin-4; Nasal Polyps

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