Histopathological Study of the Liver in Balb/C Mice with Lupus Treated by Bone Marrow-Derived Mesenchymal Stem Cells (Bm-Mscs)

Esmael, Ghassan Khudhair; Ulaiwi, Hassan Khalaf; Majed, Noor Mahmood; Abd Al Hussein, Wijdan Mirza

doi:10.23975/bjvr.2024.150642.1100

	Histopathological Study of the Liver in Balb/C Mice with Lupus Treated by Bone Marrow-Derived Mesenchymal Stem Cells (Bm-Mscs)
Basrah Journal of Veterinary Research
Volume 23, Issue 3, September 2024, Pages 24-33 PDF (868.52 K)
Document Type: Research Paper
DOI: 10.23975/bjvr.2024.150642.1100
Authors
Ghassan Khudhair Esmael¹; Hassan Khalaf Ulaiwi²; Noor Mahmood Majed^* ³; Wijdan Mirza abd Al Hussein⁴
¹branch of Internal medicine/ veterinary medicine college/ University of Al-Qadisiyah/ iraq
²Branch of Internal medicine / veterinary medicine college/ Al-Qadysiyah university/ Iraq
³college of dentistry/ college of -Qadysiah
⁴branch of Basic science/ college of dentistry / university of Al-Qadysiah / Iraq
Abstract
lupus is an autoimmune disease that occurs in animals and humans, characterized by producing autoimmune antibodies against its cells proteins. The present study investigates the tissues changes of the liver in BALB/c mice with lupus and investigation the effects of bone marrow-derived mesenchymal stem cells (BM-MCSs) for treatment of the tissues pathological changes. The study included forty BALB/c mice, the animals divided into equally four groups. G1 included mice with lupus. G2 included mice with lupus, then treated by BM-MCSs. G3 are administered BM-MCSs alone. G4 administrated PBS. After ending the treatment periods, all the animals were sacrificed. The liver was placed in buffer formalin 10% and sent to the histopathology laboratory to determine the histopathological changes in all study groups. The histopathological changes of G1 are liver severe necrosis with atrophy, hydropic lever cells, very wide sinusoids, severe hemorrhage, and engorged central vein. G2 showed normal lever cells with slight necrosis. G3 and G4 showed normal architecture of the liver tissue. Lupus causes histopathological changes in the mice's liver; MSC can ameliorate and treat the liver's histopathological changes in BLAB/c mice with lupus.
Keywords
Histopathological Examination; liver; BALB/c mice; lupus; MSCs

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