Histopathological Changes of Applying Nano-Fat on Articular Cartilage Degenerative Defect in A Dog Model

Abokhamsen, Ali Wasfi; Khashjoori, Bassim Khadim

doi:10.23975/bjvr.2024.150398.1093

	Histopathological Changes of Applying Nano-Fat on Articular Cartilage Degenerative Defect in A Dog Model
Basrah Journal of Veterinary Research
Volume 23, Issue 3, September 2024, Pages 106-117 PDF (1.4 M)
Document Type: Research Paper
DOI: 10.23975/bjvr.2024.150398.1093
Authors
Ali Wasfi Abokhamsen^* ¹; bassim Khadim khashjoori²
¹Karbala university
²basrah university
Abstract
Damage to articular cartilage can ultimately lead to osteoarthritis, a debilitating degenerative joint disease. Treating cartilage damage is difficult because cartilage has a limited ability to heal itself and because currently available treatments are limited. Nano-fat tissue, a specific type of adipose tissue, comprises the greatest concentration of MSCs, fibroblasts, and pericytes. This study was conducted to evaluate the efficacy of Nano-fat on healing of articular cartilage in dogs. Methods Ten healthy adult mongrel dogs were used in current study, The dogs were divided into two equal groups (n = 5), Group I (the control group) was left without treatment. While group II (the nano-fat group) was treated by the application of nano-fat. Result, showed that the signs of mineralization occur in the peripheral portion, particularly in the edges near the trochlear groove of joint, while operation site of control group was filled with collagen fibres, and newly generated blood vessels are evident and numerous. Control group was not featuring cartilage regeneration Conclusion, Nano-fat used as a treatment can effectively enhance articular cartilage regeneration, enhance the newly generated blood vessels and accelerate the inflammatory process.
Keywords
articular cartilage; articular cartilage degenerative defect; Nano-fat; dogs’ osteoarthritis

Statistics Article View: 238 PDF Download: 163