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Anion Gap and Electrolytes Disturbance in Iraqi Children With Celiac Disease | ||
| Journal of Education and Science | ||
| Article 4, Volume 34, Issue 1, January 2025, Pages 30-36 PDF (492.86 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/edusj.2024.152731.1490 | ||
| Author | ||
| Nadia Saad Ali* | ||
| Medical chemistry, Ministry of Health, Baghdad, Iraq | ||
| Abstract | ||
| Background:Celiac disease is a genetic autoimmune disorder; children with celiac disease may have malabsorption, electrolytes and acid-base disturbance. Electrolytes like ( Sodium, Potassium, and Chloride) have an essential role in maintaining blood pressure. At the same time,bicarbonate and anion gap are the best ways to measure the body's acid-base balance. Objective:The study aims to measure electrolytes (Sodium, Potassium,and Chloride) to determine the electrolyte disturbance and to measure the Bicarbonate and anion gap to determine the acid-base imbalance in the celiac disease group compared to the control group. Methods: Fifty children have been included in this study ( twenty untreated celiac disease and thirty control children). Three milliliters of venous blood samples were taken, Gold-top serum separator tubes were used to obtain the serum, then Sodium, Potassium, Chloride, and Bicarbonate were measured by kinetic method, and the anion gap was calculated using the equation: Anion gap=[ (Sodium +Potassium) – (Chloride +Bicarbonate)] Results: Patients with untreated celiac disease suffer from severe hyponatremia with mild hypochloremia (p values < 0.001, 0.023 ), respectively. However,neither Potassium andBicarbonate concentrations nor the Anion gap have been affected. Conclusions: Acid-base imbalance and electrolyte disturbance didn’t usually occur in children with celiac disease who suffer from mild symptoms, while Sodium and Chloride concentrations decreased due to their loss through diarrhea. | ||
| Keywords | ||
| Sodium; Potassium; Chloride; Bicarbonate; Anion gap | ||
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