Dawood, R., Najem, R., Ali, A., Farhan, R. (2024). The Correlation of Human Leukocyte Antigen (HLA) Haplotypes with Clinical and Laboratory Profiles of Celiac Disease in Children. , 23(3), 270-278. doi: 10.52573/ipmj.2024.137433
raghad Dawood; Raghad Dawood Najem; Arabiya Idan Ali; Rabab Farhan. "The Correlation of Human Leukocyte Antigen (HLA) Haplotypes with Clinical and Laboratory Profiles of Celiac Disease in Children". , 23, 3, 2024, 270-278. doi: 10.52573/ipmj.2024.137433
Dawood, R., Najem, R., Ali, A., Farhan, R. (2024). 'The Correlation of Human Leukocyte Antigen (HLA) Haplotypes with Clinical and Laboratory Profiles of Celiac Disease in Children', , 23(3), pp. 270-278. doi: 10.52573/ipmj.2024.137433
Dawood, R., Najem, R., Ali, A., Farhan, R. The Correlation of Human Leukocyte Antigen (HLA) Haplotypes with Clinical and Laboratory Profiles of Celiac Disease in Children. , 2024; 23(3): 270-278. doi: 10.52573/ipmj.2024.137433

The Correlation of Human Leukocyte Antigen (HLA) Haplotypes with Clinical and Laboratory Profiles of Celiac Disease in Children

Iraqi Postgraduate Medical Journal
Volume 23, Issue 3, July 2024, Pages 270-278    PDF (321.79 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2024.137433
Authors
raghad Dawood* 1; Raghad Dawood Najem* 2; Arabiya Idan Ali2; Rabab Farhan3
1Ministry of Health
2Central Teaching Hospital of Pediatric
3Pediatric Consultant Pediatric Gastroenterology College of Medicine/ Baghdad .
Abstract
Background:Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is the major protein component of wheat, rye, and barley, the major predisposing genes are the HLA-DQ2 and DQ8 genotypes found in at least 95% of patients. Achieving early diagnosis of coeliac disease is critical to ensuring good lifelong health and providing children with the ability to thrive .
Objective:To demonstrate the profiles of coeliac disease (the way in which coeliac disease present , to find out age and sex distribution , endoscopical and histopathological finding) and to analyze the correlation of HLA haplotypes with clinical and laboratory profiles of coeliac disease in children.
Patients and methods:A retrospective study was done on forty children and adolescents of ≤14 years old of age, with clinical diagnosis of celiac disease, whom attended the pediatric gastroenterology outpatient clinic of Children Welfare Teaching Hospital in Baghdad city.
Results:
The mean age was 8.1 year. Female were 21(52.5%), male were 19(47.5%). Short stature was the commonest chief complaints in 20 patients (50%). The commonest histopathological finding Marsh 3 was the commonest in 27(67.5%) patients.
HLA typing system: 15 patients labeled as DQ2 (37.5%), 12 patients labeled as DQ8 (30%), 12 patients were having both DQ type (30%). The dominant haplotype was DQB1*02, The higher proportion of those with DQ2 or DQ8 or both aged 5-10 years (DQ2 46.7% , DQ8 41.7% , both 50.0%).. Anti_tissuetransglutaminase IgA was positive in all of those having both DQ2 and DQ8 100%.
Conclusion:This result showed that patient with sever histopathology ( Marsh 3 ) carried HLA -DQ risk alleles and in other side Marsh 1 or 2 carried low or no HLA-DQ risk alleles, patient with at least one DQB1*02 allele showed high expression of clinical and histological presentation of coeliac disease.
Keywords
Celiac,,; ,،,؛disease,,; ,،,؛humen,,; ,،,؛leukocyte,,; ,،,؛antigen haplotype
Full Text
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