Synthesis and characterization of Mn(II),Co(II),Ni(II),Cu(II) and Zn(II) complexes with heterocyclic ligands and evaluation of its biological activity.

Abdljabar, Roaa R.; Tariq, Farah

doi:10.33899/rjs.2024.185384

	Synthesis and characterization of Mn(II),Co(II),Ni(II),Cu(II) and Zn(II) complexes with heterocyclic ligands and evaluation of its biological activity.
Rafidain Journal of Science
Article 8, Volume 33, Issue 4, December 2024, Pages 56-68 PDF (1.17 M)
Document Type: Research Paper
DOI: 10.33899/rjs.2024.185384
Authors
Roaa R. Abdljabar¹; Farah Tariq²
¹Department of Chemistry/ College of Science/ University of Mosul
²Dept. of Chem., College of Science, Mosul University
Abstract
Solid phase one-pot multicomponent reaction was used of heterocyclic compounds due to its supreme properties starting from three component mixture of piperonal binzil, p-phenylene diamine and ammonium acetate which was synthesized through reflux for 6 hours to afford 1-N(p-aminophenyl)-2-(piperonyl-5-yl) -5-hydroxy-4,5-diphenyl-2H-imidazole, which then converted to N-(4-(2-(benzo-1,3-dioxol-5-yl)-4,5-diphenyl-2,5-dihydro-1H-idazol-1-yl)phenyl) benzamide through its reaction with benzoyl chloride in the presence of triethylamine as a base catalyst. Further the Mn(II), Co(II), Ni(II), Cu(II) and Zn (II) complexes were synthesized by direct reaction of the above ligand with metal chlorides in (1:1) or (2:1) (Ligand:metal) molar ratio in ethanolic medium. The prepared complexes were characterized by elemental analysis, spectral studies (FTIR., UV/vis), ¹H-NMR measurement, conductivity measurements, magnetic measurement and electronic spectra values indicate the presence of tetrahedral and octahedral geometric around the metal ions and the study of inhibiting effect on the growth of different types of bacteria which are strains staphylococcus aurous and Klebsiella pneumoniae. The results indicate that the compound (4) has a great effect on different types of bacteria compared to the rest of the complexes, which gave a higher effectiveness rate.
Keywords
Ammonium acetate; reflux; ethanolic medium; diphenyl; characterized

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