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Role of Interleukin-17A and Interleukin-23 as Biomarkers in Rheumatoid Arthritis Patients | ||
| Annals of the College of Medicine, Mosul | ||
| Volume 46, Issue 2, December 2024, Pages 177-183 PDF (556.31 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/mmed.2024.146968.1254 | ||
| Authors | ||
| Ikram Al_hasso* 1; Salim Mohammed Saeed Al jader2 | ||
| 1Microbiology, college of medicine,Mosul, Iraq | ||
| 2Department of rheumatology and medical rehabilitation, Teaching hospital of Al-Salam, Nineveh Health Directorate, Mosul, Iraq. | ||
| Abstract | ||
| Background: Cytokines are crucial in the mechanisms underlying inflammation and articular degeneration accompanying the autoimmune disease rheumatoid arthritis. Interleukine-17 and interleukine-23 were shown to have a key function in the chronic immune process and the consequent tissue destruction in the joints of rheumatoid patients. Aims: The study goal was to quantify interleukins-17A and IL-23 concentrations in a group of newly diagnosed rheumatoid patients and to evaluate if there is a linkage between these cytokines and the activity parameters of this illness. Subjects and Methods: A study involving 250 individuals, 125 rheumatoid patients, and 125 controls was performed. The ELISA technique utilized Blood samples to estimate interleukines-17A and -23. Results: Rheumatoid cases had higher IL-17A (median= 49.7 pg/ml) and IL-23 (mean= 21.1 ng/L) concentration, P < 0.05, than controls. IL-17A was shown to be positively correlated with DAS-28 (P<0.01), С-reactive protein (r= 0.036, P < 0.01), and ESR value (r = 0.021, P < 0.05). The AUC for IL-17A= 0.742, and IL-23=0.804 with P < 0.05). Conclusion: Both interleukine17-A and IL-23 possess value in the pathogenesis of rheumatoid arthritis, and it is possible to use them as biomarkers for disease diagnosis and to predict the prognosis of the disease. | ||
| Keywords | ||
| Rheumatoid arthritis; cytokine; interleukins; biomarker | ||
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