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Irisin and physiological effects on human metabolic processes | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 18, Issue 2, December 2024, Pages 23-30 PDF (709.15 K) | ||
| Document Type: Review Paper | ||
| DOI: 10.37652/juaps.2024.144249.1174 | ||
| Authors | ||
| Anwar Abd Saiel* 1; Luma Dali2; Yusser Mahmoud Ragheb3; Haneen ziyad Abdullah4 | ||
| 1College of Medicine/ University of Anbar - Rammadi - Iraq | ||
| 2University of Anbar/ college of Basic Education/ Haditha | ||
| 3Department of Biology/ College of Science/ University of Anbar | ||
| 4Department of Biotechnology/ College of Science/ University of Anbar- Rammadi - Iraq | ||
| Abstract | ||
| Irisin is a newly discovered hormone that is released from the skeletal muscles when exercising. Genetically, exercise primarily increases PGC-1α expression in cardiac and skeletal muscles. It also develops several metabolic parameters, such as insulin sensitivity and signaling, starts the process of activating AMP-activated protein kinase (AMPK), phosphorylating PGC-1α, and producing fibronectin typeIII domain containing protein 5 ( FNDC5), which cleaves FNDC5 and produces irisin. It is distributed throughout the body and has a physiological effect on several tissues and organs, as it involves several functions. It has a role in the browning of white adipose tissue releases energy stored as heat and thus maintaining the body's balance. It has a role in insulin resistance; it maintains body mass and thus reduces obesity. Therefore, studying the expression and function of physiological, Irisin may open several horizons in its use as a treatment for many diseases such as type II diabetes, obesity, heart disease, and many other diseases. This article reviews the research progress on the role of Irisin on the physiological state of humans. | ||
| Keywords | ||
| Irisin hormone; Myokin; Insulin Resistance; Nervous system; obesity | ||
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