- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Assessment of the Effect of Selenium Nanoparticles on Virulence Genes Expression csgD, adrA, and gcpA of Multi-Drug Resistant Salmonella enterica | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 18, Issue 2, December 2024, Pages 5-15 PDF (606.57 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2024.146103.1178 | ||
| Authors | ||
| mariam Ayad Ayad* 1; Sawsan Q. T. Al-Quhli2; Mahir Ali Jassim3 | ||
| 1Department microbiology , College of Medicine, University of Anbar | ||
| 2Department of Microbiology, College of Medicine, University of Anbar,Ramadi,Iraq, | ||
| 33 Internal Medicine Department, College of Medicine, University of Anbar | ||
| Abstract | ||
| This study explores the use of Selenium nanoparticles (SeNPs) to combat multi-drug resistant (MDR) Salmonella enterica serovars Typhi and Typhimurium, with a focus on their biofilm formation and antibiotic resistance patterns. The research involved isolating these Salmonella serovars from clinical samples, assessing their biofilm-forming abilities using the Microtiter plate assay, and analyzing their resistance to various antibiotics. A significant finding of this study is the high propensity of Salmonella isolates to form biofilms on plastic surfaces, raising concerns for infection control and food safety. The antibiotic susceptibility tests revealed an alarming level of multi-drug resistance, particularly in isolates from immunocompromised patients. This resistance was evident against frontline antibiotics like chloramphenicol, amoxicillin, and ceftriaxone. Notably, the study demonstrates that SeNPs, when combined with antibiotics, significantly improve their effectiveness. This enhancement is particularly evident in the reduced expression of biofilm- and virulence-related genes such as adrA, gcpA, and csgD. SeNPs could be a promising approach in treating resistant Salmonella infections, offering a potential solution to the escalating problem of antibiotic resistance. Overall, the study highlights the urgent need for alternative treatments against MDR Salmonella and suggests that SeNPs might be an effective option, warranting further research for clinical application. | ||
| Keywords | ||
| SALMONELLA; GENE EXPRESION; ANTIBIOTIC RESISTANCE | ||
|
Statistics Article View: 941 PDF Download: 315 |
||