Hassan, D., Mustafa, Y., Altalbawy, F. (2025). Advancements in the Synthesis and Biomedical Impacts of Molecules Incorporating 1,3-Dioxolane. , 22(2), 99-115. doi: 10.33899/iraqij.p.2025.155007.1120
Duha Adnan Hassan; Yasser Fakri Mustafa; Farag M.A. Altalbawy. "Advancements in the Synthesis and Biomedical Impacts of Molecules Incorporating 1,3-Dioxolane". , 22, 2, 2025, 99-115. doi: 10.33899/iraqij.p.2025.155007.1120
Hassan, D., Mustafa, Y., Altalbawy, F. (2025). 'Advancements in the Synthesis and Biomedical Impacts of Molecules Incorporating 1,3-Dioxolane', , 22(2), pp. 99-115. doi: 10.33899/iraqij.p.2025.155007.1120
Hassan, D., Mustafa, Y., Altalbawy, F. Advancements in the Synthesis and Biomedical Impacts of Molecules Incorporating 1,3-Dioxolane. , 2025; 22(2): 99-115. doi: 10.33899/iraqij.p.2025.155007.1120

Advancements in the Synthesis and Biomedical Impacts of Molecules Incorporating 1,3-Dioxolane

Iraqi Journal of Pharmacy
Article 6, Volume 22, Issue 2, June 2025, Pages 99-115    PDF (1.02 M)
Document Type: Review Paper
DOI: 10.33899/iraqij.p.2025.155007.1120
Authors
Duha Adnan Hassan* 1; Yasser Fakri Mustafa1; Farag M.A. Altalbawy2
1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
2Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia
Abstract
Background: Numerous synthetic health-related products contain the 1,3-dioxolane ring (DOR) as a valuable constituent in their chemical structures. According to several structure-activity relationships, adding this heterocyclic ring to the compound's chemical framework could enhance various types of activities. These include anticancer, antifungal, antiviral, antibacterial, antioxidant, and anti-inflammatory effects. Aim: The current issue of negative drug reactions and resistance requires the creation of effective agents with new frameworks that can handle these pharmacological obstacles. In this review, the main focus is on new in-lab methods to make compounds that contain DOR and improve the biological effectiveness of medicines by using a new synthetic DOR's chemical structure. Methods: This review was conducted by the authors using a variety of databases, such as Web of Science, Google Scholar, PubMed, and Scopus, without specifying the publication dates. Results: The unique way that synthetic compounds with DOR are made and how well they work in medicine make experts want to do more research in this area. It is found by the investigators that the addition of this heterocyclic ring could enhance many biological activities for various bioactive agents. Conclusion: As indicated by a number of studies, the two oxygen atoms in the DOR backbone may enhance the studied ring's functionality. These atoms are believed to form hydrogen bonds with the active site. This improves the interactions between the ligand and the target, and consequently, the presence of this heterocyclic ring enhances biological activity.

Highlights
  • Synthetic health products often contain the 1,3-dioxolane ring (DOR) in their chemical structures.
  • The addition of this ring can enhance various activities such as anticancer, antifungal, antiviral, antibacterial, antioxidant, and anti-inflammatory effects.
  • The current issue of negative drug reactions and resistance necessitates the development of effective agents with new frameworks.
  • The review focuses on new in-lab methods to create compounds with DOR and improve the biological effectiveness of medicines.
  • The presence of the heterocyclic ring enhances biological activity by forming hydrogen bonds with the active site.
Keywords
1,3-Dioxolane; Antibacterial; Anticancer; Antioxidant; Bioactivity; Heterocyclic
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