Attarbashee, R. (2025). Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats. , 22(1), 8-13. doi: 10.33899/iraqij.p.2025.155197.1121
Rana Khairi Attarbashee. "Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats". , 22, 1, 2025, 8-13. doi: 10.33899/iraqij.p.2025.155197.1121
Attarbashee, R. (2025). 'Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats', , 22(1), pp. 8-13. doi: 10.33899/iraqij.p.2025.155197.1121
Attarbashee, R. Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats. , 2025; 22(1): 8-13. doi: 10.33899/iraqij.p.2025.155197.1121

Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats

Iraqi Journal of Pharmacy
Article 2, Volume 22, Issue 1, March 2025, Pages 8-13    PDF (691.98 K)
Document Type: Research Paper
DOI: 10.33899/iraqij.p.2025.155197.1121
Author
Rana Khairi Attarbashee*
Department of Dental Basic Sciences, College of Dentistry, University of Mosul, Mosul, Iraq
Abstract
Background and objective: Although methotrexate has been utilized over many years, adverse effects are frequent throughout therapy, especially among cancer patients. The study examined the efficacy of bosentan as a protective therapy against tongue toxicity induced by methotrexate. Methods: This study employed twenty-four 300–400 g Wister-albino rats. The animals were categorized into three groups: methotrexate (80 mg/kg), methotrexate (80 mg/kg) plus bosentan (60 mg/kg), and control healthy (distilled water). The tongue mucosa was subjected to biochemical and immunohistochemical analysis. The animals' tongue mucosa was dissected immediately following they were euthanized on day 16. Results: In contrast to the control group, the Methotrexate group had significantly higher levels of TNF-α, IL-1β and MDA (p < 0.05). However, the Methotrexate+Bosentan group displayed considerably lower levels of TNF-α, IL-1β and MDA in contrast to the Methotrexate group, (p < 0.05). Conclusion: These findings demonstrate that bosentan protect considerably against methotrexate-induced tongue toxicity in rats.
Keywords
Bosentan; Methotrexate; Oxidative stress; Tongue toxicity
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