S. Thanoon, N., Alnori, M., Saeed Alchalabi, A., M. Alghrer, M. (2025). Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City. , 22(1), 31-37. doi: 10.33899/iraqij.p.2025.155434.1122
Nuha S. Thanoon; Mohammed KJ. Alnori; Ali Saeed Alchalabi; Madyan M. Alghrer. "Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City". , 22, 1, 2025, 31-37. doi: 10.33899/iraqij.p.2025.155434.1122
S. Thanoon, N., Alnori, M., Saeed Alchalabi, A., M. Alghrer, M. (2025). 'Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City', , 22(1), pp. 31-37. doi: 10.33899/iraqij.p.2025.155434.1122
S. Thanoon, N., Alnori, M., Saeed Alchalabi, A., M. Alghrer, M. Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City. , 2025; 22(1): 31-37. doi: 10.33899/iraqij.p.2025.155434.1122

Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City

Iraqi Journal of Pharmacy
Article 5, Volume 22, Issue 1, March 2025, Pages 31-37    PDF (845.14 K)
Document Type: Research Paper
DOI: 10.33899/iraqij.p.2025.155434.1122
Authors
Nuha S. Thanoon1; Mohammed KJ. Alnori* 2; Ali Saeed Alchalabi3; Madyan M. Alghrer4
1Ninevah Health Director, Ninevah, Iraq
2Department of Clinical Laboratory Sciences, College of Pharmacy, University of Mosul, Mosul, Iraq
3Department of Physiology, Pharmacology, and Biochemistry, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
4Alhadbaa Teaching Hospital, Ninevah Health Director, Ninevah, Iraq
Abstract
Background: α-thalassaemia is mostly caused by deletions in the alpha-globin gene complex, which result in either reduced or absent α-globin chain synthesis. β-globin chains are either absent or decreased in ß-thalassemia. Analyzing the regulatory genes (foxO1 and hepcidin) for iron and ferritin, in thalassemic patients was the goal of this study. Methods: Fifty individuals  were selected for this study. Ten participants (5 females and 5 males) were healthy when they were recruited from general community and visited Al-Hadba'a Hospital (Mosul City) for blood withdrawal, while the forty patients (20 females and 20 males) have thalassaemia and ranged in age from 8 to 17.  Results: Male participants had higher levels of iron and ferritin than female participants. Furthermore, there were notable differences in between male and female thalassaemic subjects. Additionally, ferritin and HbF were directly correlated with iron level and sex. Hepcidin expression analysis in healthy rather than thalassaemic participants found both down- and up-regulation; forkhead box O1 (foxO1) expression analysis demonstrated the reverse hemoglobin types pattern. Conclusion: In both thalassaemic and healthy subjects, gender was associated with the serum levels of iron, ferritin, and the genes that regulate them. Hepcidin and foxO1 synchronized with iron and ferritin in the human body.
Keywords
Thalassemia; Iron; Hemoglobin; Ferritin; Foxo1; Hepcidin
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