Mohammod, Z., Alnakash, A. (2025). Relation between Maternal Triglyceride, Cholesterol Levels and Amniotic Fluid Index in Women with Gestational Diabetes Mellitus to Newborn Birth Weight at Term. , 24(1), 35-41. doi: 10.52573/ipmj.2025.143800
Zubaida Jassium Mohammod; Abdulrazak H. Alnakash. "Relation between Maternal Triglyceride, Cholesterol Levels and Amniotic Fluid Index in Women with Gestational Diabetes Mellitus to Newborn Birth Weight at Term". , 24, 1, 2025, 35-41. doi: 10.52573/ipmj.2025.143800
Mohammod, Z., Alnakash, A. (2025). 'Relation between Maternal Triglyceride, Cholesterol Levels and Amniotic Fluid Index in Women with Gestational Diabetes Mellitus to Newborn Birth Weight at Term', , 24(1), pp. 35-41. doi: 10.52573/ipmj.2025.143800
Mohammod, Z., Alnakash, A. Relation between Maternal Triglyceride, Cholesterol Levels and Amniotic Fluid Index in Women with Gestational Diabetes Mellitus to Newborn Birth Weight at Term. , 2025; 24(1): 35-41. doi: 10.52573/ipmj.2025.143800

Relation between Maternal Triglyceride, Cholesterol Levels and Amniotic Fluid Index in Women with Gestational Diabetes Mellitus to Newborn Birth Weight at Term

Iraqi Postgraduate Medical Journal
Article 6, Volume 24, Issue 1, January 2025, Pages 35-41    PDF (596.38 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2025.143800
Authors
Zubaida Jassium Mohammod* 1; Abdulrazak H. Alnakash2
1Iraqi Board in Obstetrics and Gynecology
2Obstetrician and Gynecologist Alkindy College of Medicine University of Baghdad Al-Elwiya Maternity Teaching Hospital
Abstract
exaggerated and may indicate underlying metabolic dysfunction that transiently manifests during pregnancy.
Aim of study: To identify the relation between maternal triglyceride and cholesterol levels and amniotic fluid index in the obstetric population with gestational diabetes mellitus to the newborn birth weight.
Methods: A cross sectional study conducted at Obstetrics and Gynecology Department in Al-Elwyia Maternity Teaching Hospital in Baghdad, including 100 pregnant women (gestational age ≥ 37 weeks) having gestational diabetes mellitus. Serum total cholesterol, triglyceride, and glucose concentrations and amniotic fluid index were measured then neonatal birth weight was measured at labor.
Results: In this study, 12% of study patients had high cholesterol level and 47% had high Triglyceride level and 32% had high amniotic fluid index. Mean birth weight was significantly higher in babies delivered by patients with dyslipidemia than that in those delivered by patients without dyslipidemia. A positive correlation was detected between birth weight and with both S. cholesterol S. triglyceride. But no statistical significant correlation detected between amniotic fluid index and birth weight.
Conclusion: S. Cholesterol and triglyceride levels in gestational diabetes pregnant women could be significantly correlated with neonatal birth weight unlike the amniotic fluid index.
Keywords: Gestational DM, triglyceride, cholesterol, AFI, birthweight.
Keywords
Keywords: Gestational DM; triglyceride; cholesterol; AFI; birthweight
References
  1. Ojo O, Weldon SM, Thompson T, Vargo EJ. The effect of vitamin d supplementation on glycaemic control in women with gestational diabetes mellitus: A systematic review and meta-analysis of randomised controlled trials. International journal of environmental research and public health. 2019; 16:1716.
  2. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normalpregnancy and gestational diabetes. Diabetes Care. 2007; 30: S112–9.
  3. Genevay M, Pontes H, Meda P. Beta cell adaptation in pregnancy: a major difference between humans and rodents. Diabetologia. 2010;53:2089–89.
  4. Wendland EM, Torloni MR, Falavigna M, Trujillo J, Dode MA, Campos MA, et al. Gestational diabetes and pregnancy outcomes—a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria. BMC Pregnancy Childbirth. 2012;12:23.
  5. Farrar D, Simmonds M, Bryant M, Sheldon TA, Tuffnell D, Golder S, et al. Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis.BMJ.2016;354:i4694.
  6. Garber AJ. Vascular disease and lipids in diabetes. Medical Clinics. 1998;82:931-48.
  7. Kitajima M, Oka S, Yasuhi I, Fukuda M, Rii Y, Ishimaru T. Maternal serum triglyceride at 24–32 weeks’ gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstetrics & Gynecology. 2001;97:776-80.
  8. Maternal Physiology, Essentials of obstetrics and gynaecology, 2nd ed, USA, WB Saunders Company, 1995;6:61-73.
  9. Wang D, Xu S, Chen H, Zhong L, Wang Z. The associations between triglyceride to high‐density lipoprotein cholesterol ratios and the risks of gestational diabetes mellitus and large‐for‐gestational‐age infant. Clinical endocrinology. 2015;83:490-97.
  10. Murray E, Fernandes M, Fazel M, Kennedy SH, Villar J, Stein A. Differential effect of intrauterine growth restriction on childhood neurodevelopment: asystematic review. BJOG: An International Journal of Obstetric & Gynecology . 2015; 122:1062-72.
  11. Ta S. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37:81-90.
  12. Herrera E, Ortega-Senovilla H. Disturbances in lipid metabolism in diabetic pregnancy–are these the cause of the problem?. Best practice & research Clinical endocrinology & metabolism. 2010;24:515-25.
  13. KITAJIMA M, OKA S, Yasuhi IFM, Rii Y, Ishimaru T. Maternal serum triglyceride at 24-32 weeks' gestation and newborn weight in non-diabetic women with positive diabetic screens. Obstet Gynecol. 2001; 97:776-80.
  14. Herrera E, Amusquivar E,lopez-Soldado l, Ortega H Maternal lipid metabolism and placental lipid transfer. Horn Res.2006; 65:59-64.
  15. Schaefer – Graf U, Graf K, Kulbacka I, Kjos SL, Dudenhausen J, Velter KE, et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care. 2008;17:97–103.
  16. Ling-Dar Hwang et al.effect of maternal lipid concentrations on offspring birth weight. Int J Epidemiol .2019;48:1457-67.
  17. Varma TR, Patel RH, Pillai U.The relationship of increased amniotic fluid volume to perinatal outcome. Int J Gynecol Obstet.1988 ;27:327-33.
Kofinas, A. & Kofinas, G. Differences in amniotic fluid patterns and fetal biometric parameters in third trimester pregnancies with and without diabetes. J Matern Fetal Neonatal Med.2006; 19: 633–38.

Statistics
Article View: 313
PDF Download: 129


Journal Management System. Powered by iJournalPro.com