Age and Sex Modulate Albumin, Glomerular Filtration Rate, and Lipid Profile in Type 2 Diabetic Patients

Tchewonpi Choumessi, Aphrodite; Foudjou Saha, Brice Ulrich; Yuefebop, Tafrie; Muankang, Junior Kum Tegha; Tsague Manfo, Faustin Pascal; Akono Nantia, Edouard

doi:10.33091/amj.2025.155323.2014

	Age and Sex Modulate Albumin, Glomerular Filtration Rate, and Lipid Profile in Type 2 Diabetic Patients
Al- Anbar Medical Journal
Volume 21, Issue 2, April 2025, Pages 123-128 PDF (338.3 K)
Document Type: Original articles
DOI: 10.33091/amj.2025.155323.2014
Authors
Aphrodite Tchewonpi Choumessi¹; Brice Ulrich Foudjou Saha¹; Tafrie Yuefebop¹; Junior Kum Tegha Muankang¹; Faustin Pascal Tsague Manfo²; Edouard Akono Nantia^* ¹
¹Department of Biochemistry, Faculty of Science, University of Bamenda, PO Box 39 Bambili, Cameroon.
²Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, PO Box 63 Buea, Cameroon.
Abstract
Background: Metabolic factors associated with type 2 diabetes mellitus (T2DM) remain poorly understood, especially in the context of population-specific influences and varying environmental settings. Objectives: To investigate the modulation of albumin, lipid profile biomarkers, and glomerular filtration rate (eGFR) in T2DM patients attending the Bamenda Regional Hospital in Cameroon. Materials and Methods: Briefly, 153 patients were interviewed on their socio-demographic and anthropometric information, and their fasting blood glucose (FBG) level, lipid profile, albumin, and eGFR were determined. Results: The majority (61.4%) of participants were females and almost half (45.7%) of the population was obese. The FBG level was lower in the older age group (70-79 years, 165.62±17.95 mg/dL) than those moderately younger (≤69 years, 241.26±12.96 mg/dL). Also, the eGFR (65.97±4.03 ml/min/1.73m²) and high-density lipoprotein (HDL) level (54.06±2.84 mg/dL) decreased in older patients, particularly in the age 70-79 years. Male participants had higher albumin levels than the females (4.77±0.12 g/dL vs. 4.38±0.11 g/dL). Moreover, albumin was higher in the younger population (39-49 years; 4.99±0.22g/dL) as compared to older individuals (80-89 years; 4.07±0.22 g/dL). Correlation analyses revealed significant associations of FBG, albumin, eGFR, triglycerides, HDL, and low-density lipoprotein with age, gender, and body mass index. Conclusion: The findings suggested significant variations in albumin, lipid biomarkers, and eGFR among diabetic patients, with age, gender, and cholesterol levels being the key modulators. Older patients seem particularly affected, making them a critical group for targeted management of T2DM.
Keywords
Confounding factors; Glomerular filtration rate; Lipid parameters; Serum albumin; Type 2 diabetes mellitus

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