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Synthesis and Characterization of Azetidine-2-One and Pyridazine Derivatives from Substituted Benzimidazole. | ||
| Rafidain Journal of Science | ||
| Volume 34, Issue 1, March 2025, Pages 43-51 PDF (801.06 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rjs.2025.186494 | ||
| Authors | ||
| Sedra Ahmad AlKhayat* 1; salim jasim mohamed* 2 | ||
| 1طالبة دراسات عليا/ ماجستير علوم كيمياء | ||
| 2Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| In this work, the azetidine substitutes and pyridazine compounds derived from benzimidazole substitute were prepared by two routes, where the first route included the preparation of the benzimidazole substitute (SA1) with a high yield, then it was reacted with ethyl chloroacetate in the presence of a base to obtain the corresponding ester (SA2) and then the ester was converted to hydrazide (SA3) by reacting the ester (SA2) with aqueous hydrazine, and the hydrazide (SA3) was reacted with different aldehydes to obtain azetidine derivatives (SA9-13), while the second route included the reaction of hydrazide with maleic anhydride, succinic anhydride and phthalic anhydride to obtain pyridazine compounds (SA14,15,16). The prepared compounds were characterized physically and spectroscopically by both 1H -NMR and FT-IR. | ||
| Keywords | ||
| Benzimidazole substitute; azetidine; pyridazine; hydrazone | ||
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