Bioactivity effects of phlorizin extract on diabetic mice compared to Metformin

Abed, Widad Rahman; Alethari, Ishtar Adnan

doi:10.29079/qjvms.2024.152671.1033

	Bioactivity effects of phlorizin extract on diabetic mice compared to Metformin
Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 24, Issue 1, January 2025, Pages 31-40 PDF (516.05 K)
Document Type: Research Paper
DOI: 10.29079/qjvms.2024.152671.1033
Authors
Widad Rahman Abed; Ishtar Adnan Alethari^*
Department of Physiology, Pharmacology, and Biochemistry, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Diwaniyah City, Iraq
Abstract
Diabetes mellitus (DM) is a metabolic disorder that is characterized by hyperglycemia and glucose intolerance. Type 2 diabetes is the most common type of diabetes and accounts for approximately 90% of all diabetes cases with insulin resistance and impaired insulin secretion. Insulin resistance (IR) is the main pathological feature, as well as hypertension and dyslipidemia. This study aims to evaluate the effect of phlorizin extract in improving the symptoms associated with diabetes compared to metformin. In the present study, T2DM was induced by streptozotocin (STZ) (40 mg/kg, intraperitoneally) in male rats on a high-fat diet. Hence, the needs to develop new methods of treatment, the diabetic rats were assigned to receive two types of treatment: phlorizin (100 mg/kg/day) and metformin (250 mg/kg/day). Random levels of blood glucose, serum insulin, free fatty acids, total cholesterol, triglycerides and low-density lipoprotein, were detected in T2DM rats. The main goal of anti-diabetic therapy is to reduce the amount of glucose in the blood and increase the development of immunity. Phlorizin showed promising efficacy comparable to metformin in the management of diabetes and helped improve blood glucose levels, glucose tolerance and insulin sensitivity in mice with T2DM in the treated groups, in addition to reducing fat accumulation.
Keywords
Anti-diabetic therapy; Diabetes; Glucose; Metformin; Phlorizin

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