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Spectrophotometric determination of Cisapride Based on ion-pair complex formation with Bromophenol blue | ||
| journal of kerbala university | ||
| Article 1, Volume 5, Issue 4, 2009, Pages 143-151 PDF (0 K) | ||
| Abstract | ||
| A new simple, sensitive and inexpensive method has been developed for the spectrophotometric determination of cisapride in pharmaceutical formulation. The turbidimetric method is based on the formation of the ion-pair complex between the drug and bromophenol blue (BPB) in presence of potassium chloride at pH= 2.6, with a maximum absorbance at 520 nm. The calibration graph is linear in the concentration range 5-50µg.ml-1, with good correlation coefficient (r = 0.9989).The limit of detection was found to be 1.14 µg.ml-1 and no interference was observed from common excipients in the pharmaceutical preparation that contain cisapride with good accuracy and precision | ||
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