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Assessing the Effect of Intranasal Sedation with Midazolam on Reducing Anxiety in Patients Undergoing Mandibular Third Molars Surgery | ||
| Al-Rafidain Dental Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 04 April 2025 | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rdenj.2024.145628.1240 | ||
| Authors | ||
| Rawaa Saad Salim* 1; Ziad Hazim Deleme* 2; Ahmed Salih Khudhur* 3 | ||
| 1Oral and Maxillofacial Surgery Department/Nineveh Health Directorate, Mosul, Iraq | ||
| 2Department of Oral and Maxillofacial Surgery /College of Dentistry/University of Mosul, Iraq | ||
| 3Department of Oral Diagnosis, College of Dentistry, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| Aims: To evaluate the efficacy of intranasal sedation with Midazolam on reducing anxiety in patients undergoing surgical removal of impacted mandibular third molars. Materials and methods: Thirty healthy individuals were included in this study of both genders; their age ranged between (18-40) years, whom were looking for surgical removal of impacted mandibular third molars under local anesthesia and they possessed moderate to severe grades of anxiety. Patients were randomly distributed into two groups: Midazolam group included fifteen patients premedicated with intranasal Midazolam using a nasal spray in concentration of 0.2 mg/kg body weight ten minutes before surgery, Placebo group included fifteen patients received oral Placebo of glucose powder capsule one hour before surgery. The following parameters were assessed: systolic blood pressure, diastolic blood pressure and anxiety score. Results: Regarding systolic blood pressure measurements: there was a statistically significant difference between Midazolam and Placebo groups after drug administration, there was a highly significant difference between Midazolam and Placebo groups during the surgical procedure as well as at the end of the surgical procedure. Regarding diastolic blood pressure measurements: there was a highly statistically significant difference between Midazolam and Placebo groups after drug administration, during the surgical procedure and at the end of the surgical procedure. Regarding anxiety: there was a highly significant difference between Midazolam and Placebo groups post-operatively. Conclusions: Intranasal administration of Midazolam is recommended as a safe, reliable and effective conscious sedation for anxious patients during surgical removal of impacted mandibular third molars. | ||
| Keywords | ||
| Molars; Anxiety; Intranasal; Midazolam; Sedation | ||
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