STUDY THE ROLE OF NIGELLA SATIVA AQUATIC EXTRACTED IN  STAMULATION  OF THE IMMUNITY RESPONSE

	STUDY THE ROLE OF NIGELLA SATIVA AQUATIC EXTRACTED IN STAMULATION OF THE IMMUNITY RESPONSE
journal of kerbala university
Article 1, Volume 6, Issue 3, 2010, Pages 44-49 PDF (0 K)
Abstract
Sixty white males mice involved in this study. The range of their age were 8-12 weeks, divided into four groups treatment, each one included three replicates, each replicate include 5 mice, weighted 22g. Aquatic extract prepared from Nigella sativa seeds. Different doses (0, 200, 300, and 500) mg/kg body weight orally applied for 30 consecutive days. Later the ratio of thymus /body, spleen/body, macrophage activities and delayed hypersensitivity (DTH) were determined by standard methods. The thymus index and the (DTH) significant increase p≤0.05 at the concentration of (300, 500) mg/kg body weight from the aquatic extract of N. sativa seeds, but the spleen index not recorded any significant increase as compared with control. The ability of macrophages to phagocyte and the activity of macrophages revealed significant increase p≤0.05 at all concentration (200, 300, and 500) mg/kg body weight but the best was at 500 mg/kg. The results of this study showed that the best concentration were (300, 500) mg/kg body weight.
Keywords
Nigella sativa; Immune effect; aquatic extract

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