Al-Mahdawi, D., Al-Talib, N. (2025). The Effect of Oxcarbazepine on Thyroid Hormone Levels in Epileptic Patients. , 24(2), 251-258. doi: 10.52573/ipmj.2025.149354
Dhuha Akram Al-Mahdawi; Nameer Mohammed Al-Talib. "The Effect of Oxcarbazepine on Thyroid Hormone Levels in Epileptic Patients". , 24, 2, 2025, 251-258. doi: 10.52573/ipmj.2025.149354
Al-Mahdawi, D., Al-Talib, N. (2025). 'The Effect of Oxcarbazepine on Thyroid Hormone Levels in Epileptic Patients', , 24(2), pp. 251-258. doi: 10.52573/ipmj.2025.149354
Al-Mahdawi, D., Al-Talib, N. The Effect of Oxcarbazepine on Thyroid Hormone Levels in Epileptic Patients. , 2025; 24(2): 251-258. doi: 10.52573/ipmj.2025.149354

The Effect of Oxcarbazepine on Thyroid Hormone Levels in Epileptic Patients

Iraqi Postgraduate Medical Journal
Article 15, Volume 24, Issue 2, April 2025, Pages 251-258
Document Type: Research Paper
DOI: 10.52573/ipmj.2025.149354
Authors
Dhuha Akram Al-Mahdawi* ; Nameer Mohammed Al-Talib
Al-Yarmouk Teaching Hospital, Baghdad, Iraq
Abstract
Abstract

Background: patients with epilepsy need long-term anti-seizure medication; several studies ‎found that anti-seizure medication affects endocrine function, including the thyroid gland.‎

Aim of the study: Assess the impact of Oxcarbazepine therapy on thyroid function test outcomes in epilepsy patients on Oxcarbazepine therapy.

Methods: a cross-sectional study was conducted at Baghdad Teaching Hospital‎, including 65 patients with epilepsy who used oxcarbazepine as a mono-antiepileptic drug. ‎The epidemiological data include the type of epilepsy (focal), ‎duration of the disease, duration of treatment, dosage of treatment, thyroid stimulating ‎hormone (TSH), thyroxin (T4), and triiodothyronine (T3) levels were tested.‎

Results: The study group showed notable associations between the length and dosage of oxcarbazepine treatment and thyroid function level. ‎

Conclusion: There is a significant difference in TSH, T3, and T4 levels ‎in patients receiving oxcarbazepine as monotherapy in correlation to its duration of use ‎and to its dose; in the analysis, the correlation observed is in duration >5 years and dosage ‎‎>600mg/day.‎
Keywords
anti-seizure medication; epilepsy; thyroid hormones
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