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The Reference Value Of Thyroid Stimulating Hormone For Children Under Age Of Five Years In Nineveh Province, Iraq | ||
| Annals of the College of Medicine, Mosul | ||
| Volume 47, Issue 1, June 2025, Pages 7-12 PDF (344.57 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/mmed.2024.153701.1284 | ||
| Authors | ||
| Asmaa Talal Mahmood* 1; Hazim Mohammed Allawi2; Ahmed Hekmat Shakir3 | ||
| 1Department of Biochemistry, College of Medicine, University of Mosul , Mosul , Iraq | ||
| 2College of Health and Medical Technologies, Alnoor University, Mosul, Nineveh, Iraq | ||
| 3Department of Medicine, College of Medicine, University of Nineveh , Mosul , Iraq | ||
| Abstract | ||
| Background: Reference ranges of thyroid-stimulating hormones are needed for diagnosing and monitoring children's thyroid disorders based on age and sex. Aims: The main objective of this study is to establish thyroid-stimulating hormone reference ranges for healthy children below five years old in Nineveh province, Iraq, based on age and sex. Methods: A cross-sectional study was conducted on one hundred sixty-six healthy children (84 males, 82 females, aged from 2 days to 5 years), and their blood samples were collected at Ibn Al-Atheer and AL-Khansaa Teaching Hospital at Nineveh, Iraq, from October 2023 - March 2024. They were divided into three groups: G1=0–1 months, G2= 1–12 months, and G3=1–5 years. Serum TSH was measured using the enzyme-linked fluorescent assay method (ELFA) by Biomerieux Mini Vidas. Result: Because of the non-normally distributed data of TSH, reference values were determined using the 2.5% and 97.5 % percentiles. Highly significant difference (p<0.02) among mean TSH(µIU/ml) of G 1(5.57±7.86), G 2 (2.67±1.80) and G 3 (2.64±1.72) for males and highly significant difference (p<0.001) among mean TSH G 1(6.01±5.94), G 2 (2.18±1.82) and G 3 (2.91±1.71)for females. Conclusions: Higher TSH values are encountered in the G1 with no sex difference of mean TSH, yet the 2.5th%-97.5th% percentile for males is evidently higher than that of females of similar age groups. | ||
| Keywords | ||
| Reference ranges; pediatric; iodine deficiency; Mini Vidas | ||
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