The Role of Colchicine in Treatment of knee Osteoarthritic Patients

Hussein, Fakhir Yousif; Younis, Ali Abdul-Rahman; Assim, Zahraa Amer; Mustafa, Khalid Naf'i

doi:10.33899/mmed.2025.152494.1280

	The Role of Colchicine in Treatment of knee Osteoarthritic Patients
Annals of the College of Medicine, Mosul
Volume 47, Issue 1, June 2025, Pages 79-83 PDF (388.14 K)
Document Type: Research Paper
DOI: 10.33899/mmed.2025.152494.1280
Authors
Fakhir Yousif Hussein^* ; Ali Abdul-Rahman Younis^* ; Zahraa Amer Assim; Khalid Naf'i Mustafa
Department of Medicine, College of Medicine, University of Mosul, Mosul, Iraq
Abstract
*Background:* The treatment of osteoarthritis was analgesia, and physiotherapy with intra-articular steroid injection improved the symptoms of the disease. It was found that cartilage damage will enhance an inflammatory process. *Aim:* This study assesses the adjuvant effect of treatment with colchicine and analgesia in knee osteoarthritis. *Methods:* This study includes 60 patients confirmed to have osteoarthritis of knee joints as diagnosed by a rheumatologist. Blood tests include ESR and CRP as inflammatory markers. We divided the patients into two groups matching age and gender; the duration of treatment and follow-up was 8 weeks. The first group enrolled 30 patients who received paracetamol (2 g/day) with physiotherapy; the other group enrolled 30 patients who received colchicine with a dosage of 0.5 mg daily and analgesics (2 g/day) and physiotherapy for the same period. *Results:* Colchicine had significantly improved knee pain by 44.7%. Visual Analogue Scale-pain score (45.20 ± 12.9 to 24.9 ± 12.9, p<0.001). *Conclusion:* Colchicine appears to be useful for treating knee osteoarthritis. It improves pain and decreases the need for joint replacement.
Keywords
Osteoarthritis; colchicine; paracetamol; physiotherapy

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