Comparative Assessment of Lactate Dehydrogenase (LDH) Enzyme Levels in Saliva and Serum among Patien

Irhayyim, Noor Sabah

doi:10.25130/tjds.12.2.3

	Comparative Assessment of Lactate Dehydrogenase (LDH) Enzyme Levels in Saliva and Serum among Patien
Tikrit Journal for Dental Sciences
Volume 12, Issue 2, December 2024, Pages 272-279 PDF (277.65 K)
DOI: 10.25130/tjds.12.2.3
Author
Noor Sabah Irhayyim^*
Department of Periodontology, College of dentistry, Tikrit University, Tikrit, Iraq
Abstract
Periodontal disease is a significant ailment that should be prioritized in community health check-up programs given its asymptomatic nature, early detection of the illness would be optimal, may be even before the patient exhibits any symptoms. Lactate dehydrogenase, often known as LDH, is an enzyme that can be found in the cytoplasm of almost every cell in the human body. When a cell dies, LDH is released into the extracellular space. The present study aims to compare the concentrations of lactate dehydrogenase (LDH) in saliva and serum samples of individuals with periodontal diseases. The objective is to identify any differences in LDH levels between these two bodily fluids. The case-control research included 200 people aged between 25 and 50 years old. The participants were categorized into two cohorts: 150 individuals with chronic periodontitis, and 50 control subjects who had excellent overall health and exhibited a healthy gum condition. The blood and saliva samples were collected simultaneously from the individuals after a comprehensive periodontal examination to assess the levels of lactate dehydrogenase enzyme. The analysis indicated that men with chronic periodontitis had a mean age of 40 years, whereas females in the control group with healthy periodontium had 27 years.CP patients had higher mean values for clinical periodontal indices PLI, GI, BOP, PPD, and CAL: 2.37, 2.12, 33.23, 4.25, and 4.55.LDH characteristic results showed that the CP group had a substantially higher mean blood enzyme level of 250 than the control group in saliva (123). The comparison showed no significant difference in LDH levels between saliva and serum in both the CP group and the control group.LDH levels in both saliva and serum rose as periodontal disease progressed. There was no statistically significant difference between saliva and serum LDH levels. Salivary LDH estimation may be utilized as a risk predictor in patients with periodontal disease.
Keywords
periodontal diseases lactate dehydrogenase

Statistics Article View: 427 PDF Download: 226