Localization Of Procollagen Type I N-Terminal Propeptide in Bone Healing Treated by Local Application of Moringa Oliefera /Marine Collagen in Rats

Al Azzawi, Areej Salim; M.H. Al-Ghaban, Nada

doi:10.25130/tjds.10.2.9

	Localization Of Procollagen Type I N-Terminal Propeptide in Bone Healing Treated by Local Application of Moringa Oliefera /Marine Collagen in Rats
Tikrit Journal for Dental Sciences
Volume 10, Issue 2, December 2022, Pages 167-175 PDF (780.11 K)
DOI: 10.25130/tjds.10.2.9
Authors
Areej Salim Al Azzawi^* ¹; Nada M.H. Al-Ghaban²
¹Department of Oral Diagnosis , College of Dentistry,University of Tikrit , Iraq
²Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Iraq
Abstract
Backgrounds: Bones healing is a complex multi steps process, Moringa Oliefera”s flavonoids and Marine collagen enhance minerals density of bones.Objectives: Differences in healing process in bones where evaluated in this study among bone defects that heal normally ( control group) and (experimental groups) using Marine collagen (MC), Moringa oleifera extract (MO) and combination of (MO &MC). Material and Methods: in this study twenty albino rats, after anesthesia bone defects were created in both femurs by drilling. In ten rats, the right bone defects left to heal normally, and left MO added to the bone defects, in other ten rats MC added to the right bone defects, left defects treated with MO & MC. Rats were scarified after 2 and 4 weeks. Immunohistochemical analysis of bone marrow stromal cells, osteocytes, osteoblasts and osteoclasts done using Procollagen type I N-terminal Propeptide (PINP). Results: Immunohistochemical result revealed stronger positive expression of PINP in bone defects treated with (MO&MC) than that other groups Conclusions: Treatment of bone defects with MO and MC showed increase osteogenic capacity by increase the immunoreactivity of PINP.
Keywords
Moringa oliefera Marine collagen PINP bone

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