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Assessment of Serum Netrin-1 Levels in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 19, Issue 1 - Serial Number 19, May and June 2025, Pages 128-136 PDF (710.53 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2024.149721.1257 | ||
| Authors | ||
| Istabraq Ahmed Shihab* 1; Khalid Farouq Abdulghafoor2; Hazim Ismael Ghazzay3 | ||
| 1Department of Chemistry, College of Science, University of Anbar, Ramdi,Iraq; | ||
| 2University of Anbar, Continuing Education Center. | ||
| 3Department of Internal Medicine, College of Medicine, University of Anbar, Iraq | ||
| Abstract | ||
| Background: Although the role of Netrin-1 in cardiovascular disease and inflammation is an emerging area of study, there is a limited amount of literature data available and a knowledge gap exists on the topic. Therefore, our research aimed to evaluate serum Netrin-1 levels in acute coronary syndrome (ACS) patients with and without type 2 diabetes mellitus (T2DM). Methods: This study comprised a group of 60 patients diagnosed with ACS. The participants were categorized into two cohorts: 30 patients with both ACS and T2DM and 30 patients with ACS but without T2DM. The control group comprised 30 healthy individuals who matched the patient groups regarding sex and age. Levels of serum Netrin-1, lipids, fasting blood glucose (FBG), Hemoglobin A1c (HbA1c), Cardiac Troponin I (cTnI), and routine blood tests were estimated. Results: The levels of Netrin-1 in the serum were significantly higher in ACS with T2DM or ACS without T2DM patients compared to healthy individuals (53.38 pg/mL and 45.57 pg/mL vs. 32.37 pg/mL, respectively, P < 0.001). The data analysis exhibited a significant positive correlation between serum Netrin-1 levels and BMI in the ACS with T2DM (r = 0.498; P = 0.005) and a significant positive correlation between serum Netrin-1 levels and Troponin I in the ACS without T2DM (r = 0.436; P = 0.02). The Netrin-1 ROC curve showed a clear cut-off value (39.99, 37.91) when calculated in ACS, with and without T2DM respectively. Conclusion: Netrin-1 levels are higher in ACS patients, both with and without T2DM, compared to healthy individuals. | ||
| Keywords | ||
| Acute coronary syndrome; Atherosclerosis; Netrin-1; Troponin I; Type 2 Diabetes Mellitus | ||
| References | ||
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