- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Expression of Budding Uninhibited by Benzimidazole Related-1 and Telomerase in Perilesional Area of Oral Squamous Cell Carcinoma | ||
| Tikrit Journal for Dental Sciences | ||
| Volume 9, Issue 1, June 2021, Pages 43-51 PDF (387.08 K) | ||
| DOI: 10.25130/tjds.9.1.6 | ||
| Author | ||
| Dena Nadhim Mohammad* | ||
| Assist. prof., Oral Diagnosis Department, College of Dentistry, University of Sulaimani, Sulaimani, Kurdistan, Iraq. | ||
| Abstract | ||
| Objective: The premalignant lesions are regarded as intermediate conditions for subsequent cancer development.Even clinically, normal-appearing mucosa could harbor early precancerous genetic mutations. This study determines the immunohistochemical expression of Budding uninhibited by benzimidazole related-1 (BubR1) and Telomerase in the perilesional area of oral squamous cell carcinoma. Materials and methods: The study involved thirty-three formalin-fixed paraffin embedded blocks of the perilesional area of oral cancer. The stain distribution, subcellular localization, and intensity of these two markers in response to their cellular localization were determined and then related to Byrne’s grading system. Fisher’s exact test and spearman’s rho test were applied to analyze the data. P≤0.05 is considered significant. Results: BubR1 showed prominent, continuous distribution in the full thickness of perilesional samples (54.5%). The subcellular localization of BubR1 was significantly related to Byrne's grading system (P≤0.001).High discontinuous distribution of telomerase throughout the epithelia was detected (63.6%). Byrne's grading system showed high significant relations to both stain distribution and subcellular localization of telomerase, as P- values were .001 and .002, respectively. Both markers showed high significant full thickness localization of buccal mucosa.Conclusions: Both makers overexpression through multiple layers of oral epithelia in the perilesional area might determine their valuable role in the early detection of oral cancer. Furthermore, the significant mixed subcellular localization of these markers in high-grade cancer could delineate their combined role in developing the second primary tumor. | ||
| Keywords | ||
| BubR1; perilesional area; stain distribution; Keywords | ||
|
Statistics Article View: 394 PDF Download: 104 |
||