- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Study the Association of Endostatin with some Anthropometric Measurements and Blood Pressure in Iraqi Women with Rheumatoid Arthritis | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 19, Issue 1 - Serial Number 19, May and June 2025, Pages 166-173 PDF (773.23 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2024.150362.1264 | ||
| Authors | ||
| Nusiba I.S. Alalwani* 1; Shakir F. T. Alaaraji2 | ||
| 1Department of Chemistry , College of Education for Pure Science, University of Anbar, Ramadi, Iraq. | ||
| 2Department of Chemistry , College of Education for Pure Science, University of Anbar, Ramadi, Iraq. | ||
| Abstract | ||
| Autoimmune disorder, Rheumatoid arthritis (RA) which is most public disease that effected systems of the body and unknown etiology. RA is diagnosis by inflammation in the synovial joints mainly small joints and hyperplasia of synoviocytes causing erosion of joint, bone and articular damage. present study targeted to evaluate serum Endostatin levels in women with RA and to estimate any possible association of serum Endostatin levels with Anthropometric measurement and Blood pressure parameters. present study consisted 56 women those with RA and 28 were matched age as healthy controls (HCs), Endostatin serum Level was evaluated by ELISA. The width of waist (W.W), width of hip (W.H), width of thoracic (W.T) and width neck (W.N) were counted , along with body mass index (BMI) for all individuals . Serum levels of Endostatin (ng/mL) in RA patients were significantly decreasing in patients than in HCs. RA patients showed higher levels of white Blood Cells (WBC), lower levels of hemoglobin (Hb) (g/dL) and non-differences in Red Blood Cells (RBC) levels between patients and HCs. Decreased serum concentrations of Endostatin was exhibited a negatively relationship with ratio of waist to thoracic (W/T), ratio of waist to neck (W/N), WBCs, RBCs and Systolic Blood pressure (SBP)(mmHg), while positive association of Endostatin with waist to hip ratio (W/H), Diastolic Blood Pressure (DBP)(mmHg), Hb, and Body Mass Index (BMI) (Kg/m2) was noticed. Serum levels of endostatin showed very weak and non-significant correlations with all variables studied | ||
| Keywords | ||
| Anthropometric measurement SBP; DBP; WBCs and RBCs | ||
| References | ||
|
[1] Q. N. Baito, H. M. Jaafar, and T. A. M. Mohammad, "Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition," Cellular Immunology, vol. 391, p. 104752, 2023.
[2] M. Gulati, Z. Farah, and M. Mouyis, "Clinical features of rheumatoid arthritis," Medicine, vol. 46, no. 4, pp. 211-215, 2018.
[3] V. C. Romão and J. E. Fonseca, "Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review," Frontiers in medicine, vol. 8, p. 689698, 2021.
[4] M. Li, Z. Popovic, C. Chu, B. K. Krämer, and B. Hocher, "Endostatin in renal and cardiovascular diseases," Kidney Diseases, vol. 7, no. 6, pp. 468-481, 2021.
[5] M. Grant and R. Kallur, "Structural basis for the functions of endogenous angiogenesis inhibitors," in Cold Spring Harbor symposia on quantitative biology, 2005, vol. 70: Cold Spring Harbor Laboratory Press, pp. 399-417.
[6] Z. Szekanecz, T. Besenyei, G. Paragh, and A. E. Koch, "Angiogenesis in rheumatoid arthritis," Autoimmunity, vol. 42, no. 7, pp. 563-573, 2009.
[7] H. Wang, Y. Chen, X.-a. Lu, G. Liu, Y. Fu, and Y. Luo, "Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis," Diabetes, vol. 64, no. 7, pp. 2442-2456, 2015.
[8] E. Kucharz et al., "A single infusion of infliximab increases the serum endostatin level in patients with rheumatoid arthritis," Clinical and experimental rheumatology, vol. 21, no. 2, pp. 273-273, 2003.
[9] N. Y. Assaf, A. Faramawy, M. A. Bassett, and N. Elwan, "Possible role of serum levels of vascular endothelial growth factor and endostatin in rheumatoid arthritis angiogenesis imbalance," Egyptian Rheumatology and Rehabilitation, vol. 34, no. 3, pp. 417-426, 2007.
[10] R. L. Mirwald, A. D. Baxter-Jones, D. A. Bailey, and G. P. Beunen, "An assessment of maturity from anthropometric measurements," Medicine & science in sports & exercise, vol. 34, no. 4, pp. 689-694, 2002.
[11] X. Feng et al., "Body mass index and the risk of rheumatoid arthritis: an updated dose-response meta-analysis," BioMed research international, vol. 2019, 2019.
[12] M. M. Ismail and S. F. Alaaraji, "An exploration of the relationship between interleukin 37, 8-ohdg and a number of anthropometric measurements in iraqi rheumatoid arthritis patients," EurAsian Journal of BioSciences, vol. 14, no. 1, 2020.
[13] L. Bautista, L. Vera, I. Arenas, and G. Gamarra, "Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension," Journal of human hypertension, vol. 19, no. 2, pp. 149-154, 2005.
[14] J. A. Avina-Zubieta, J. Thomas, M. Sadatsafavi, A. J. Lehman, and D. Lacaille, "Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies," Annals of the rheumatic diseases, vol. 71, no. 9, pp. 1524-1529, 2012.
[15] S. Gabriel, "Heart disease in rheumatoid arthritis: changing the paradigm of systemic inflammatory disorders," The Journal of Rheumatology, vol. 34, no. 1, pp. 220-223, 2007.
[16] S. F. T. Alaaraji, "Exploration of the Relationship between Interleukins 17, 37 and 38 with Vitamin E in Iraqi Men with CHB," in Journal of Physics: Conference Series, 2019, vol. 1294, no. 5: IOP Publishing, p. 052047.
[17] H. S. Mahmoud and S. F. Alaaraji, "A relationship of contactin-1 with a number of trace elements in Iraqi rheumatoid arthritis patients with and without COVID-19."
[18] F. C. Arnett et al., "The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis," Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, vol. 31, no. 3, pp. 315-324, 1988.
[19] A. Ardanny, "Pathophysiology and Management of Refractory Rheumatoid Arthritis: A Narrative Literature Review," Bioscientia Medicina: Journal of Biomedicine and Translational Research, vol. 8, no. 4, pp. 4239-4246, 2024.
[20] Y. Wang, H. Wu, and R. Deng, "Angiogenesis as a potential treatment strategy for rheumatoid arthritis," European Journal of Pharmacology, vol. 910, p. 174500, 2021.
[21] C. Faye, E. Chautard, B. R. Olsen, and S. Ricard-Blum, "The first draft of the endostatin interaction network," Journal of biological chemistry, vol. 284, no. 33, pp. 22041-22047, 2009.
[22] W. Hu et al., "Recombinant human endostatin inhibits adjuvant arthritis by down-regulating VEGF expression and suppression of TNF-α, IL-1β production," Inflammation Research, vol. 61, pp. 827-835, 2012.
[23] S. M. O’Brien, P. Fitzgerald, P. Scully, A. Landers, L. V. Scott, and T. G. Dinan, "Impact of gender and menstrual cycle phase on plasma cytokine concentrations," Neuroimmunomodulation, vol. 14, no. 2, pp. 84-90, 2007.
[24] H. J. Kadhim et al., "The Relationship between Obesity and Rheumatoid Arthritis," Journal of Current Medical Research and Opinion, vol. 6, no. 12, pp. 1914-1926, 2023. | ||
|
Statistics Article View: 468 PDF Download: 130 |
||