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Evaluation of Immunohistochemical Expression of P53 and Pcna in Pleomorphic Adenoma, Mucoepidermoid and Adenoid Cystic Carcinomas of Salivary Glands | ||
| Tikrit Journal for Dental Sciences | ||
| Volume 3, Issue 1, June 2013, Pages 1-8 PDF (603.9 K) | ||
| DOI: 10.25130/tjds.2013.1.1 | ||
| Authors | ||
| Layla S. Al-Ani BDS, MSc1; Lehadh M. Al-Azzawi2 | ||
| 1(1)Lecturer, Department of Oral Maxillofacial Pathology, Collage of Dentistry, University of Baghdad | ||
| 2(2)Ass. Prof., Department of Oral Maxillofacial Pathology, Collage of Dentistry, University of Baghdad. | ||
| Abstract | ||
| Salivary gland tumours are uncommon with a broad heterogeneity. The most common benign tumour is the pleomorphic adenoma, whereas mucoepidermoid carcinoma and adenoid cystic carcinoma predominate among the malignancies. The aim of this study was to describe the tissue expression of p53 and PCNA protein in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma and to compare their expression among the studied tumors. The study enrolled (45)formalin –fixed, paraffin- embedded tissue blocks of salivarygland tumors, diagnosed as pleomorphicadenoma, mucoepidermoid carcinoma and adenoid cysticcarcinoma (15 cases for each ) and evaluated theimmunohistochemical expression of P53 and PCNA proteins. The study revealed positive p53 protein expression in (60%) ofmuocoepidermoid carcinoma cases and (20%) of adenoid cysticcarcinoma cases, while only one case (6.7%) of pleomorphicadenoma was P53 positive. The immunopositivity of PCNAprotein expression was found in (100%) of both mucoepidermoidcarcinoma and adenoid cystic carcinoma cases and (66.7%) ofpleomorphic adenoma cases. The results of this study demonstrated that inactivation of p53protein may play an important role in the activation of PCNA withincreasing the proliferation activity of MEC and ACC. | ||
| Keywords | ||
| mucoepidermoid carcinoma adenoid cystic carc | ||
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