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A Comparative Study of Liver and Kidney Function Indicators in Patients with Beta-thalassemia Major and Beta-thalassemia Trait | ||
| Al- Anbar Medical Journal | ||
| Volume 21, Issue 3, July 2025, Pages 191-197 PDF (936.42 K) | ||
| Document Type: Original articles | ||
| DOI: 10.33091/amj.2025.158019.2143 | ||
| Authors | ||
| Enaam Ahmed Hamza AL-Dagestani1; Mohammad Ahmad Hamza* 2; Nabaa Yahyaa Yusif3 | ||
| 1Department of Medical Physics, College of Science, University of Mosul, Mosul, Iraq. | ||
| 2Department of Chemistry, College of Science, University of Zakho, Duhok, Iraq. | ||
| 3Department of Biophysics, College of Science, University of Mosul, Mosul, Iraq. | ||
| Abstract | ||
| Background: Comparative analysis of liver and kidney function in patients with beta-thalassemia major (BTM) and beta-thalassemia trait (BTT) is relatively underexplored in the existing literature. Objectives: This study compares liver and kidney function in children with BTM, BTT, and healthy controls, and investigates the potential protective role of ferritin in reducing iron-related tissue damage in BTT patients. Materials and methods: A case-control study was conducted on 93 male children (ages 2–12) from Ibn Al-Atheer and Ibn Sina Hospitals in Mosul, Iraq, divided into three groups: BTM (31), BTT (31), and healthy controls (31). Serum levels of liver and kidney biomarkers (ALT, AST, ALP, DBIL, TBIL, urea, creatinine, uric acid, and ferritin) were measured. Statistical analysis was performed using SPSS (version 26.0) with a significance level of P-value < 0.05. Results: In the BTM group, levels of ALP, AST, urea, and uric acid were significantly higher compared to the control group, while no significant differences were observed between the BTT and control groups for these parameters. ALT, TBIL, DBIL, creatinine, and ferritin levels were elevated in both BTM and BTT groups relative to controls. Notably, all parameters except TBIL were significantly higher in the BTM group than in the BTT group. Additionally, a significant positive correlation was observed between ferritin and ALP in the BTM group, whereas a significant negative correlation was found between ferritin and creatinine in the BTT group. Conclusion: BTM significantly impaired liver and kidney function, while BTT showed mild increases in ALT, TBIL, DBIL, creatinine, and ferritin. In BTM, ferritin correlated with ALP, indicating potential iron toxicity, whereas in BTT, the negative correlation with creatinine may suggest a protective mechanism. Further research is needed to clarify ferritin thresholds for toxicity versus protection. | ||
| Keywords | ||
| liver; kidney; Beta thalassemia trait; Beta-thalassemia Major | ||
| References | ||
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[1] S. Patel, A. Siddiqui, and I. Kareem, "Correlative study of serum bilirubin and liver enzymes with serum ferritin in beta thalassaemia major," IOSR Journal of Dentaland Medical Sciences, vol. 17, no. 2, pp. 62-67, 2018.
[2] G. De Simone, A. Quattrocchi, B. Mancini, A. di Masi, C. Nervi, and P. Ascenzi, "Thalassemias: from gene to therapy," Molecular Aspects of Medicine, vol. 84, p. 101028, 2022.
[3] A. Kattamis, G. L. Forni, Y. Aydinok, and V. Viprakasit, "Changing patterns in the epidemiology of β‐thalassemia," European journal of haematology, vol. 105, no. 6, pp. 692-703, 2020.
[4] T. Rudra, "Advanced Approaches Towards Treatment of Genetic Disorders with a special referennce to Thalassemia-A Comphrehensive," Chinese Journal of Medical Genetics, vol. 32, no. 1, 2023.
[5] G. J. Kontoghiorghes, "Iron load toxicity in medicine: from molecular and cellular aspects to clinical implications," International journal of molecular sciences, vol. 24, no. 16, p. 12928, 2023.
[6] E. Angelucci et al., "Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation," Blood, The Journal of the American Society of Hematology, vol. 100, no. 1, pp. 17-21, 2002.
[7] M. Andreani et al., "Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation," Bone marrow transplantation, vol. 25, no. 4, pp. 401-404, 2000.
[8] S. Setoodeh, M. Khorsand, and M. A. Takhshid, "The effects of iron overload, insulin resistance and oxidative stress on metabolic disorders in patients with β-thalassemia major," Journal of Diabetes & Metabolic Disorders, vol. 19, pp. 767-774, 2020.
[9] A. I. Ansaf et al., "Hypoparathyroidism in Patients Older than 10 Years of Age with Beta-thalassemia," Journal of Applied Hematology, vol. 15, no. 2, pp. 116-120, 2024.
[10] E. A. Mohammed and N. A. Muhammed, "Effect of Maternal Beta-Thalassemia Minor on Obstetrical and Neonatal Outcomes in Kirkuk Province, Iraq," Al-Anbar Medical Journal, vol. 19, no. 2, 2023.
[11] N. M. A. ATARBASHI and E. A. H. AL-DAGESTANI, "A STUDY OF SOME BIOCHEMICAL INDICATORS OF KIDNEY FUNCTION AND ESTIMATION OF SOME ELEMENTS CONCENTRATION IN THE BLOOD SERUM OF PATIENTS WITH CELIAC DISEASE," International Journal of Applied Sciences and Technology, vol. 4, no. 22, pp. 157-167, 2022.
[12] E. Voskaridou et al., "Early markers of renal dysfunction in patients with sickle cell/β-thalassemia," Kidney international, vol. 69, no. 11, pp. 2037-2042, 2006.
[13] S. M. Rabadiya, M. Yogesh, J. Nagda, R. Gandhi, and N. Makwana, "Association of serum ferritin trends with liver enzyme patterns in β-thalassemia major: A longitudinal correlational study," Journal of Family Medicine and Primary Care, vol. 13, no. 7, pp. 2698-2702, 2024.
[14] A. Faruqi, T. Zafar, S. Subuctageen, and I. A. Mughal, "Iron overload and liver function in patients with beta thalassemia major: A cross sectional study," Pakistan Journal of Medical Sciences, vol. 40, no. 9, p. 2000, 2024.
[15] K. M. Musallam et al., "Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia," Haematologica, vol. 96, no. 11, p. 1605, 2011.
[16] M. V. Sadeghi, M. Mirghorbani, and R. Akbari, "β-Thalassemia minor & renal tubular dysfunction: is there any association?," BMC nephrology, vol. 22, pp. 1-7, 2021.
[17] H. K. Jabbar, M. K. Hassan, and L. M. Al-Naama, "Lipids profile in children and adolescents with β-thalassemia major," Hematology, Transfusion and Cell Therapy, vol. 45, no. 4, pp. 467-472, 2023.
[18] V. De Sanctis, A. Eleftheriou, and C. Malaventura, "Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF)," Pediatric endocrinology reviews: PER, vol. 2, pp. 249-255, 2004.
[19] A. Y. D. Bashi and F. H. Fathi, "Evaluation of Hepatic Enzymes in major β-thalassemic Patients using Deferasirox," Iraqi Journal of Pharmaceutical Sciences, vol. 31, no. 2, pp. 237-243, 2022.
[20] S. Sobhani, F. Rahmani, M. Rahmani, M. Askari, and F. Kompani, "Serum ferritin levels and irregular use of iron chelators predict liver iron load in patients with major beta thalassemia: a cross-sectional study," Croatian medical journal, vol. 60, no. 5, pp. 405-413, 2019.
[21] I. Young and J. Woodside, "Antioxidants in health and disease," Journal of clinical pathology, vol. 54, no. 3, pp. 176-186, 2001.
[22] M. Okuda, S. Sasaki, I. Kunitsugu, R. Sakurai, N. Yoshitake, and T. Hobara, "Iron Load and Liver Enzymes in 10-and 13-year-olds," Journal of pediatric gastroenterology and nutrition, vol. 52, no. 3, pp. 333-338, 2011.
[23] Y. Y. Huang, M. J. Huang, H. L. Wang, C. C. Chan, and C. S. Huang, "Bilirubin concentrations in thalassemia heterozygotes in university students," European journal of haematology, vol. 86, no. 4, pp. 317-323, 2011.
[24] S. Bhowad, P. Samant, and B. Seth, "Biochemical assessment of renal function and its correlation with iron overloading in different variants of thalassemia," Journal of Applied and Natural Science, vol. 14, no. 3, p. 1016, 2022.
[25] M. F. Karim, M. Ismail, A. M. Hasan, and H. U. Shekhar, "Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis," International journal of hematology-oncology and stem cell research, vol. 10, no. 1, p. 7, 2016.
[26] O. Tanous et al., "Renal function in β-thalassemia major patients treated with two different iron-chelation regimes," BMC nephrology, vol. 22, pp. 1-11, 2021. | ||
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