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Optimization of Bronchodilator Treatment in COPD: A Comparison of the Glycopyrrolate/Formoterol Combination vs. Formoterol Alone | ||
| Kirkuk Journal of Medical Sciences | ||
| Volume 13, Issue 2, July 2025, Pages 6-11 PDF (697.34 K) | ||
| Document Type: Original research | ||
| DOI: 10.32894/kjms.2025.156364.1137 | ||
| Authors | ||
| Hiwa Fateh Saber* 1; Ahmed Duraid Abdullah2 | ||
| 1Anesthesia and Intensive Care Department, Hawler Teaching Hospital, Erbil, IRAQ | ||
| 2Anesthesia and Intensive Care Department, Tala’afar Hospital, Nineveh City, IRAQ | ||
| Abstract | ||
| Background: Using a glycopyrrolate/formoterol combination to manage COPD patients is considered a new method. The objectives of this study are to evaluate the effectiveness of the glycopyrrolate/formoterol combination against formoterol alone in optimizing lung function in moderate and severe COPD patients. Methods: Twenty patients with chronic obstructive pulmonary disease were of class II and III according to the ASA classification. Patients were prospectively divided into two groups: group 1 was given glycopyrrolate and formoterol metered dose inhalers, and group 2 was given a formoterol nebulizer alone. Optimization of treatment was assessed on the first day, at the second week, and at the fourth week by lung function tests (FEV1 and FVC). Results: Formoterol alone and a combination of formoterol with glycopyrrolate were well tolerated and optimized lung function. FEV1, FVC, and FEV1/FVC ratio significantly increased (p value<0.001). However, the combination of glycopyrrolate and formoterol had a better effect on lung function (FEV1 and FVC) in comparison to formoterol alone (p value<0.001) in 4 weeks of use. Conclusion: Glycopyrrolate/formoterol metered dose inhaler is more effective in the optimization of the condition of patients with COPD disease than a formoterol nebulizer alone. | ||
| Keywords | ||
| Bronchodilator; Chronic Obstructive Pulmonary Disease; Formoterol; Glycopyrrolate; Spirometry | ||
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