Study of Some Biochemical Alterations in Breast Cancer Patients

Othman, Noor Abdullah; Mohammed, Salm Khalid

doi:10.33899/rjs.2025.158710.1435

	Study of Some Biochemical Alterations in Breast Cancer Patients
Rafidain Journal of Science
Articles in Press, Accepted Manuscript, Available Online from 02 August 2025
Document Type: Research Paper
DOI: 10.33899/rjs.2025.158710.1435
Authors
Noor Abdullah Othman^* ¹; Salm Khalid Mohammed²
¹Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq.
²Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq
Abstract
Breast cancer persists as a major international medical challenge because it stands as one of the prominent causes of female cancer-related mortality. The research based on the Kurdistan Region of Iraq investigates breast cancer patients' biochemical and metabolic transformations regarding liver, renal, and lipid functions. The investigation included sixty breast cancer patients and forty subjects within the control group as part of a case-control study. Biochemical assessment determined Random blood sugar (RBS), lipid profile, and indicators that measured liver and kidney function. Evidence shows that breast cancer patients have major psychological changes that lead to heightened anxiety and despair, and show higher body mass index metrics than patients without breast cancer. Multiple research studies indicate that breast cancer exists as a measurable link to the combined presence of past miscarriage and familial tendencies for cancer development. Total cholesterol measurements combined with triglyceride levels and LDL quantities increased in patients with dyslipidemia and showed lower HDL values. Blood glucose levels increased in breast cancer patients during the research period. Renal patients had higher blood urea, elevated serum creatinine levels, and increased AST, ALT, and ALP liver enzyme activity. Still, their total bilirubin and direct and indirect bilirubin decreased. Studies underline the importance of metabolic health monitoring among breast cancer patients because detected changes in assessments can affect treatment response, with disease management. The study proves that breast cancer needs individualized care strategies that integrate metabolic care with psychological interventions, while showing important information about cancer's advanced metabolic processes.
Keywords
Breast cancer; Lipid profile; Renal function; Liver function; Metabolic alterations

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