Serum FcαRI (CD89) and Atopic Dermatitis: A Novel Investigation into Associations with White Blood Cell Subsets.

AL-Shammari, Bandar; AL-Allaff, Rojan

doi:10.33899/rjs.2025.158981.1439

	Serum FcαRI (CD89) and Atopic Dermatitis: A Novel Investigation into Associations with White Blood Cell Subsets.
Rafidain Journal of Science
Articles in Press, Accepted Manuscript, Available Online from 02 August 2025
Document Type: Research Paper
DOI: 10.33899/rjs.2025.158981.1439
Authors
Bandar AL-Shammari^* ¹; Rojan AL-Allaff²
¹University of Mosul, Faculty of Science, Department of Life Sciences
²University of Mosul Faculty of Science Department of Life Sciences, Mosul City, Iraq
Abstract
Eczema, another name for atopic dermatitis (AD), is a chronic inflammatory skin disease that causes redness, irritation. It is a common disorder affecting individuals of all ages. The human IgA Fc receptor (FcαRI/CD89) is expressed on myeloid cells, such as monocytes/macrophages, eosinophils, and neutrophils, and can trigger various immunological effector processes.The study aims to Assess the concentration of FcαRI in patients with chronic atopic dermatitis, including both children and adults, the study sought to evaluate the relationship between FcαRI levels and white blood cell counts using a regression coefficient test. A total of 110 AD patients (aged 1–30 years) were recruited from hospitals in Mosul city between October 2024 and February 2025. Participants were categorized into two age groups: children (1–15 years, n=38) and adults (16–30 years, n=32), along with age-matched healthy controls (n=40).Blood samples were analyzed for FcαRI levels using ELISA and for WBC counts through CBC analysis. The results demonstrated significantly elevated FcαRI levels in AD patients compared to controls (p ≤ 0.05),with children exhibiting higher concentrations than adults. Regression analysis identified significant correlations between FcαRI levels and WBC subpopulations. Elevated FcαRI levels in AD patients indicate immune hyperactivity and increased immune complex formation, contributing to chronic inflammation and exacerbation of AD symptoms. suggesting a decrease in FcαRI expression with age. This suggests that FcαRI may play a role in inflammatory cell recruitment and immune regulation in AD. FcαRI may serve as a valuable biomarker for assessing the severity and progression of atopic dermatitis.
Keywords
Atopic dermatitis; CD89; IgA; anti-inflammatory; auto-antibody

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