The correlation between genetic variation for SNCA gene with parkinson's disease

احمد, منار خضر

doi:10.33899/rjs.2025.159884.1454

	The correlation between genetic variation for SNCA gene with parkinson's disease
Rafidain Journal of Science
Articles in Press, Accepted Manuscript, Available Online from 02 August 2025
Document Type: Research Paper
DOI: 10.33899/rjs.2025.159884.1454
Author
منار خضر احمد^*
جامعة الموصل
Abstract
The purpose of the present research was to investigate the relationship between the alpha-synuclein gene (SNCA) and Parkinson's syndrome by collecting 120 specimens of blood from both patients as well as normal people who visited Ibn Sina Teaching Hospital in Mosul from Dec to June 2023–2024. The specimens were separated between different categories, including the Parkinson's (patient) group donated symbol P, which contained thirty specimens split into two distinct age-based subgroups, P1 (ages 50–65) and P2 (ages 66–80). Each had 15 blood samples, and the Parkinson's family record group contributed symbol F had thirty specimens of persons around the ages of 25 and 50 as well to controls group C, which had sixty specimens of people who were healthy split into three subgroups: C1 (50–65 years old) C2 (ages 66–80) and subgroupC3 (ages 25–50). Results of our study After comparison between these groups had been made showed mutation in different location in the designed part of SNCA gene sequences most of them are point mutation in family group F and Parkinson’s group P compared to the healthy group C
Keywords
Alpha-synuclein; point mutation; primer designed

Statistics Article View: 96