Cognitive Function Assessment post Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease

Hamza, Zainab Karim

doi:10.52573/ipmj.2025.145923

	Cognitive Function Assessment post Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson’s Disease
Iraqi Postgraduate Medical Journal
Article 2, Volume 24, Issue 4, October 2025, Pages 448-452 PDF (315.13 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2025.145923
Author
Zainab Karim Hamza^*
Abstract
Background: Parkinson disease (PD) is the 2nd most common neurodegenerative disorder affecting more than 6 million people allover the world. Cognitive impairment occur with variable onset during the course of disease. Surgical treatment of PD used for patients who, despite optimal medical treatment, experience motor complications, common surgical treatment is deep brain stimulation (DBS), which targets the subthalamic nucleus, globus pallidus internus, or ventral intermediate nucleus of the thalamus, but it may also cause complication as general medical complication and neurological complication. The aim of study: To assess the risk of cognitive decline post subthalamic neuclus-deep brain stimulation in patients with Parkinson disease. The patients and method: A prospective interventional study involved 14 patients with Parkinson’s disease, this study was done at Baghdad in medical science of neurology hospital, in a period from June 2022 till December 2022. Results: A 14 patients were included, the age was ranging between (55-75) years males were (8) patients while females were (6), the patients with PD, Montreal cognitive assessment test was done pre and post subthalamic neuclus-deep brain stimulation and we found significant differences between baseline and post-surgical evaluations in terms of language score verbal fluency and there is no significant difference between baseline and post-surgical assessments among other different cognitive domains of Montreal cognitive assessment test scoring. Also, the result of this study shows positive correlation and non-significant differences between Language score verbal fluency with age group, education, duration of disease, and Hohen and Yaher score. While, there’s negative correlation and significant association with gender. Conclusion: Bilateral subthalamic neuclus-deep brain stimulation for patients with Parkinson disease do not lead to a significant fall in cognitive function apart from impairment in verbal fluency.
Keywords
Parkinson; Verbal fluency; Visuospatial; DBS

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