Effect of albendazole excretion in the milk on blood parameters in suckling and adult rats

Ahmed, S. M.

doi:10.33899/ijvs.2009.189445

	Effect of albendazole excretion in the milk on blood parameters in suckling and adult rats
Iraqi Journal of Veterinary Sciences
Volume 23, Supplement 2, June 2009 PDF (1.59 M)
Document Type: Conference Paper
DOI: 10.33899/ijvs.2009.189445
Author
S. M. Ahmed
Department of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
Abstract
The present work was aimed to study the effect of albendazole excretion in the milk on blood parameters in suckling pups survived to weaning (21days of age) from mothers treated with albendazole during lactation period at dose 6.5 and 12.25 mg\kg B.W orally, As well as study the same parameters in 60^th days of the offspring. The results showed a significant decrease (P≤0.05) in red and white blood cells count and hemoglobin concentration and platelets and mean corpuscular volume and plateletscrits and in the mean cell distribution width in young at 21 days at two doses without occurrence any significant variation between the results of two doses in this study except that related to red blood cells, hemoglobin concentration, platelets, mean corpuscular volume and numbers of plateletscrits that demonstrate more decrease at dose 12.25 mg/kg. However, the blood samples that under taken from offspring after 60th day showed a significant decrease (P≤0.05) in white blood cell count, hemoglobin concentration, numbers of platelets, mean corpuscular volume and plateletscritas in comparison with control. Its concluded from this study that albendazole has a negative effect on hematopoesis process in young which exposure to it through milk, however its effect was remain in young at 60 days of age.

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