Pathological effects of ethambutol on some parts of the central nervous system of mouse embryos

Saadalla, R. K.

doi:10.33899/ijvs.2009.189472

	Pathological effects of ethambutol on some parts of the central nervous system of mouse embryos
Iraqi Journal of Veterinary Sciences
Volume 23, Supplement 2, June 2009 PDF (2.65 M)
Document Type: Conference Paper
DOI: 10.33899/ijvs.2009.189472
Author
R. K. Saadalla
Department of Biology, College of Education, University of Mosul, Mosul, Iraq
Abstract
The present study carried out to investigate at the level of light microscope. The pregnant females was ingested with ethambutol orally at 10, 15, 25 mg/kg body weight daily, which started at the 7^th day of pregnancy until 18^th day of pregnancy. The result revealed that at 10mg/kg no morphological and histological malformations. While the concentration 15 mg/kg appeared morphological malformations with ratio 14% which morphologically represented by swelling trunk, pores in ventral region of embryos. histologically there were necrosis in the anterior part of lens, rarefaction in the fibers of lens in other parts, necrosis in arch encephalon with accumulation of melanin granules in one lobules of archencephalon and coagulation in the vessels. At 25 mg/kg, the ratio of deformed embryos was 20% which morphologically represented by decrease their weight, bleeding and malformations in the left foot. Histopthologically there were injuries in the lens suchas, edema and invagination in it^,s anterior part with separation the ganglion cells of retina, a duplicated retina appeared. necrosis, vacuolation occurred in the some components of arch encephalon, and necrosis in the mesencephalon in contrast with control group.

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