Effect of levamisole on the acute toxicity of organophosphate pesticides diazinon and dichlorvos in chicks

Mansur, A. S.; Faris, G. A.

doi:10.33899/ijvs.2009.189514

	Effect of levamisole on the acute toxicity of organophosphate pesticides diazinon and dichlorvos in chicks
Iraqi Journal of Veterinary Sciences
Volume 23, Supplement 1, June 2009 PDF (2.43 M)
Document Type: Conference Paper
DOI: 10.33899/ijvs.2009.189514
Authors
A. S. Mansur; G. A. Faris
Department of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
Abstract
The purpose of this study was to study and examine the toxic interaction between Levamisole and the organophosphorus compounds (dichlorvos and diazinon) on the level of their activity on ChE and on the severity of toxicity in chciks. The injection of Levamisole at 50mg/Kg, S.C., 1/2 hr, before dosing of dichlorvos at 12 mg/Kg, or diazinon at 10 mg/Kg, oral. Significantly decreased the percentage of toxic manifestation of those compounds as well as reduced the severity of toxicity. Levamisol administration at 50 mg/Kg S.C., 30 minute before diazinon or dichlorvos decreased the percentage % of inhibitory effect the level of plasma ChE in chicks. The result indicated the levamisole may has acetylcholine (Ach) like action and stimulate the cholinergic receptors to produce cholinergic toxic signs, which not related with cholinesterase (ChE) inhibition. The present study also suggest that there is no adverse interaction between Levamisole and organphosphorus compounds (Diazinon and dichlorvos) at level of plasma ChE and on the severity of toxicity of OP compounds. Levamisole protect chicks from OP toxicity and reduced the percentage of inhibition of plasma ChE which caused by these toxic compounds.

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