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Comparative studies between propolis, dexametason and gentamycin treatments of induced corneal ulcer in rabbits | ||
| Iraqi Journal of Veterinary Sciences | ||
| Volume 23, Supplement 1, June 2009 PDF (741.41 K) | ||
| Document Type: Conference Paper | ||
| DOI: 10.33899/ijvs.2008.189541 | ||
| Author | ||
| A. A. Alfaris1, R. K. Abdulsamad1 and A. A. Swad2 | ||
| 1Department of Veterinary Internal and Preventive Medicine, Surgery & Obstetrics, 2 Department of Anatomy, College of Veterinary Medicine, University of Basrah, Basrah, Iraq | ||
| Abstract | ||
| The aim of this study was to investigate the effect of dexamethasone, propolis and gentamicin in the treatment of experimental induced corneal ulcer in rabbit. A bilateral corneal ulcer burn was induced by a filter paper disk (5mm diameter) immersed in 1N NaoH and then put it for 30 seconds on the central axis of corneas in 80 rabbits. These animals were divided equally into four groups. The corneal ulcers were treated topically as follows: Animals of the first group (control group) treated with sterile normal saline; were the animals of the second group treated with dexamethasone 0.1% eye drops> Animals of the third group were treated with aqueous extract of propolis 1%; and the animals of the forth group were treated with gentamicin eye drops 0.3%. Drugs were instilled 2 times daily (every 12 hours) for 7 days. The clinical signs of corneal ulcer were evaluated by ophthalmoscope and fluorescent technique. After sacrificing the animals the corneas underwent routine histopathological examination on the day 1st, 3rd, 5th and 10th days after the treatments. The propolis and Dexamethasone show improvement in corneal ulcer, for the first 3 days after the injury and without any signs of complication, obvious conjunctival edema and eyelid swelling were observed in control and gentamicin groups. In control group became inflamed with pus formations while in propolis and gentamicin groups remained clear without pus. Histopathological examination reveals that the infiltration of inflammatory cells in both groups of dexamethasone and propolis were fewer when it compare with groups of control and gentamicin. These findings indicate that propolis may be an alternative to others treatment of corneal ulcer. | ||
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