- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Methotrexate-induced histopathological changes in the kidneys of mice | ||
| Iraqi Journal of Veterinary Sciences | ||
| Volume 23, Supplement 2, June 2009 PDF (686.62 K) | ||
| Document Type: Conference Paper | ||
| DOI: 10.33899/ijvs.2009.189561 | ||
| Author | ||
| K. G. Chelab1 and S. Kh. Majeed2 | ||
| 1College of Veterinary Medicine, AL-Qadysia University, AL-Qadysia, 2College of Veterinary Medicine, University of Al-Basrah, Al-Basrah, Iraq | ||
| Abstract | ||
| The present study was conducted on (40) white mice of approximately the same age (4-6 weeks) and body weight (23-25 gm) for the aim of observing the histopathological changes for kidneys due to prolonged treatment (6 months) with anticancer chemotherapeutic agent namely methotrexate. Forty mice were divided into 4 groups (10 mice of each group, 5 mice per sex). The first group (low or therapeutic dose group) was received 0.15 mg/kg. The second group (intermediate dose group) received 0.3 mg/ kg. The third group (toxic dose group) received 0.45 mg / kg. The fourth dose group was a control group; it received 0.2 ml buffered normal physiological saline. All these groups injected intramuscularly, once weekly dose for 6 months. The results showed that methotrexate cause damage and severe toxicity in renal convoluted tubules and glomeruli in kidneys. | ||
|
Statistics Article View: 256 PDF Download: 100 |
||